[CIS-PAGID] quick question

[Javier Chinen]

Quality control for IVIG products required by the FDA includes measurement of antibody titers for tetanus, diphtheria, measles. Dropping titers for measles in IVIg products (and donors) in the last decade is a current concern.
The companies may include other antigens at their own initiative, such as parvovirus, hepatitis B. 

Of interest, you might also find anti-HTLV I, anti-strongyloides antibodies.

Javier Chinen



Date: Tue, 16 Aug 2011 09:44:18 -0700
From: JChurch at chla.usc.edu
To: pagid at list.clinimmsoc.org
Subject: Re: [CIS-PAGID] quick question
















The
manufacturers do some titers e.g. tetanus and measles.

 

You
could measure other antibodies in products directly after diluting
appropriately.

 

We
measured selective auto antibody titers in patients pre- and post-IVIG to show
that IVIG infusions can result in positive anti-TPO antibodies (Pediatr All
Immunol Pulmonol 2010; 23:121-3).

 

Joe
Church

Children’s
Hospital Los Angeles

 

 

-----Original
Message-----

From: pagid-bounces at list.clinimmsoc.org
[mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Sorensen, Ricardo

Sent: Tuesday, August 16, 2011 9:39 AM

To: pagid at list.clinimmsoc.org

Subject: Re: [CIS-PAGID] quick question

 

The
companies have that information. Richard Schiff has been interested

in
this issue in the past.

 

Ricardo
Sorensen

 

-----Original
Message-----

From:
pagid-bounces at list.clinimmsoc.org

[mailto:pagid-bounces at list.clinimmsoc.org]
On Behalf Of Routes, John

Sent:
Tuesday, August 16, 2011 11:25 AM

To:
pagid at list.clinimmsoc.org

Subject:
[CIS-PAGID] quick question

 

I
have a quick question--Is there a way to find out specific Ab titers

to

different
Ags in commercially available IVIG or SCIG?

thanks

 

John
M. Routes, MD

Chief,
Section of Allergy and Clinical Immunology

Professor
of Pediatrics, Medicine, Microbiology and Molecular Genetics

Department
of Pediatrics

Children's
Hospital of Wisconsin

Medical
College of Wisconsin

9000
W. Wisconsin Ave.

Milwaukee,
WI  53226-4874

 

Phone:
414-456-4802; 414-266-6997

Fax:
414-456-6487 (Clinical)

Fax:
414-456-6323 (Laboratory)

Email:
jroutes at mcw.edu

 

 

 





---------------------------------------------------------------------
CONFIDENTIALITY NOTICE: This e-mail message, including any attachments, 
is for the sole use of the intended recipient(s) and may contain confidential
or legally privileged information. Any unauthorized review, use, disclosure
or distribution is prohibited. If you are not the intended recipient, please
contact the sender by reply e-mail and destroy all copies of this original message.  

---------------------------------------------------------------------

 		 	   		  
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://seven.pairlist.net/mailman/private/pagid/attachments/20110816/de85ed45/attachment.htm>