[CIS-PAGID] Peripheral neuropathy in CVID

[Church, Joseph]

I follow a 12yo boy who had a similar experience when switched from IVIG to SC Hizentra.  His peripheral neuropathy (diagnosed by Neurology here) affects an area around the infusion sites and radiates to his scrotum.  These symptoms have persisted despite the switch back to IVIG.

The patient also has symptoms consistent with a mild form of mitochondrial disorder and has been diagnosed by our Genetics group as such.  Pain syndromes are often part of the mito picture, so I don't know if his neuropathy is related to mitochondrial dysfunction or the Hizentra infusions, both or neither.

Joe Church
Children's Hospital Los Angeles

From: pagid-bounces at list.clinimmsoc.org [mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Howard Lederman
Sent: Wednesday, April 18, 2012 12:32 PM
To: pagid at list.clinimmsoc.org
Subject: [CIS-PAGID] Peripheral neuropathy in CVID

I have an adult CVID patient who has developed an idiopathic peripheral neuropathy while on Hizentra.  My first reaction was to think that this was merely a coincidence and not cause and effect.  However, yesterday I received a call about an out-of-town patient who had CVID, had recently been switched from IVIG to Hizentra and then  developed parasthesias.

Do any of you have patients with similar histories?

Howard


Howard M. Lederman, M.D., Ph.D.
Professor of Pediatrics, Medicine and Pathology Division of Pediatric Allergy and Immunology Johns Hopkins Hospital - CMSC 1102 600 N. Wolfe Street Baltimore, MD 21287-3923
Phone: 410-955-5883
Fax: 410-955-0229
Email: Hlederm1 at jhmi.edu<mailto:Hlederm1 at jhmi.edu>

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