[CIS-PAGID] Fwd: Peripheral neuropathy in CVID

[Perez, Elena]

>From our csl connection... Regarding neuropathy discussion from yesterday

E

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From: <Elyse.Murphy at cslbehring.com<mailto:Elyse.Murphy at cslbehring.com>>
Date: April 19, 2012 8:49:57 AM EDT
To: <eperez2 at health.usf.edu<mailto:eperez2 at health.usf.edu>>
Subject: RE: Peripheral neuropathy in CVID

Hi Elena,
  I checked the pivotal trial safety results and there were no reports of paresthesias, numbness,  or tingling.   As you know, SCIg has been reported for use in some peripheral neuropathies ( CIDP, MMN) and CSL is  actually conducting a trial for SCIG use in CIDP  (PATH  trial ) and will be tracking among other parameters, Ig levels.   It has been well documented that there is a high comorbidity of autoimmune disorders with CVID – any idea  of incidence peripheral neuropathies in CVID?

  Dr Lederman should report this to our Pharmocovigilance dept..  I am not aware of any post marketing reports   but I will  check  with PKV and also ask Mel.

Best,
Elyse

From: Perez, Elena [mailto:eperez2 at health.usf.edu]
Sent: Wednesday, April 18, 2012 3:33 PM
To: Murphy, Elyse US/KOP
Subject: FW: Peripheral neuropathy in CVID

Fyi…(see below)
Any info on hizentra and paresthesia?

From: pagid-bounces at list.clinimmsoc.org<mailto:pagid-bounces at list.clinimmsoc.org> [mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Howard Lederman
Sent: Wednesday, April 18, 2012 3:32 PM
To: <mailto:pagid at list.clinimmsoc.org> pagid at list.clinimmsoc.org<mailto:pagid at list.clinimmsoc.org>
Subject: [CIS-PAGID] Peripheral neuropathy in CVID

I have an adult CVID patient who has developed an idiopathic peripheral neuropathy while on Hizentra.  My first reaction was to think that this was merely a coincidence and not cause and effect.  However, yesterday I received a call about an out-of-town patient who had CVID, had recently been switched from IVIG to Hizentra and then  developed parasthesias.

Do any of you have patients with similar histories?

Howard


Howard M. Lederman, M.D., Ph.D.
Professor of Pediatrics, Medicine and Pathology Division of Pediatric Allergy and Immunology Johns Hopkins Hospital - CMSC 1102 600 N. Wolfe Street Baltimore, MD 21287-3923
Phone: 410-955-5883
Fax: 410-955-0229
Email: <mailto:Hlederm1 at jhmi.edu> Hlederm1 at jhmi.edu<mailto:Hlederm1 at jhmi.edu>

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