[CIS-PAGID] Peripheral neuropathy in CVID

[Berger, Melvin]

Presumably, the paraesthesias are not directly related to the infusion site- ie at the site itself, or inadvertent administration into the sheath of a superficial long nerve ??
 
I have not personally heard of this. It should be breported via a medwatch to the FDA and to CSL-Behring pharmacolvigilance. They will be able to systematically review the Company's database for similar occurences. 
 
Melvin Berger, M.D., Ph.D.
Adjunct Professor of Pediatrics and Pathology
Case Western Reserve University
Cleveland, OH 44106

________________________________

From: pagid-bounces at list.clinimmsoc.org on behalf of Howard Lederman
Sent: Wed 4/18/2012 3:31 PM
To: pagid at list.clinimmsoc.org
Subject: [CIS-PAGID] Peripheral neuropathy in CVID



I have an adult CVID patient who has developed an idiopathic peripheral neuropathy while on Hizentra.  My first reaction was to think that this was merely a coincidence and not cause and effect.  However, yesterday I received a call about an out-of-town patient who had CVID, had recently been switched from IVIG to Hizentra and then  developed parasthesias. 

 

Do any of you have patients with similar histories?  

 

Howard

 

 

Howard M. Lederman, M.D., Ph.D.

Professor of Pediatrics, Medicine and Pathology Division of Pediatric Allergy and Immunology Johns Hopkins Hospital - CMSC 1102 600 N. Wolfe Street Baltimore, MD 21287-3923

Phone: 410-955-5883

Fax: 410-955-0229

Email: Hlederm1 at jhmi.edu

 

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