[CIS-PAGID] Selective IgM deficiency

[Richard Wasserman]

Joe,
I believe that there have been IgG rheumatoid factors with specificity for
IgM. If she has no measurable IgM it is hard to see how this specific
antibody would be the cause of the problem. There is not much IgM in IGSC.
In the old days when Ig protein chemistry was popular, this would have been
easy to answer with an IgM myeloma protein on a solid matrix. You might do
an immune complex assay. Have you tried daily push?
Richard Wasserman
Dallas

On Tue, May 1, 2012 at 10:26 AM, Church, Joseph <JChurch at chla.usc.edu>wrote:


>  Colleagues:****

>

> ** **

>

> I have just consulted on an woman with IgM deficiency (< 5 mg/dL) and

> selective antibody deficiency.  ****

>

> ** **

>

> She has significant reactions to her Ig infusions, even SC.****

>

> ** **

>

> Has anyone heard of IgG anti-Ig*M* antibodies causing reactions to Ig

> infusions?  ****

>

> ** **

>

> Is there any way to measure such antibodies?****

>

> ** **

>

> Joe Church****

>

> Children's Hospital Los Angeles****

>

>

> ---------------------------------------------------------------------

> CONFIDENTIALITY NOTICE: This e-mail message, including any attachments,

> is for the sole use of the intended recipient(s) and may contain

> confidential

> or legally privileged information. Any unauthorized review, use, disclosure

> or distribution is prohibited. If you are not the intended recipient,

> please

> contact the sender by reply e-mail and destroy all copies of this original

> message.

>

> ---------------------------------------------------------------------

>




-- 
Richard L. Wasserman, MD, PhD
DallasAllergyImmunology
7777 Forest Lane, Suite B-332
Dallas, Texas 75230
Office (972) 566-7788
Fax (972) 566-8837
Cell (214) 697-7211
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://seven.pairlist.net/mailman/private/pagid/attachments/20120501/e7287217/attachment.htm>