[CIS-PAGID] CVID Risk for children

[Grimbacher, Bodo]

I tell my patients 10%.
Why?
A maximum of 10-20% of CVID patients are familial (10% in AD families, and
suspected additional 10% with new mutations).
So assuming 20% of CVID patients have a Mendelian form of CVID, and most
of them seem to be autosomal-dominant, I
In AD traits the risk of any offspring is 50%.
therefore arrive at an overall risk of 10% for an offspring of newly
diagnosed CVID patients.
Yours, 
Bodo Grimbacher
CCI- Centre of Chronic Immunodeficiency
Freiburg, GERMANY


Am 05.05.12 01:27 schrieb "Church, Joseph" unter <JChurch at chla.usc.edu>:


>Colleagues:

> 

>I just consulted on a 34yo man with probable CVID.  He and his wife have

>no other medical issues.

> 

>They asked "what is the liklihood that their children (yet to be

>conceived) will develop CVID?".

> 

>I would appreciate any insight (?data) you may have.

> 

>Thank you.

> 

>Joe Church

>Children's Hospital Los Angeles

>

>

>

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