[CIS-PAGID] B-cell subset question

[Michael O'Sullivan]

Thanks to everyone who has contributed to this and the many other
interesting discussions that I've followed on this group over the past
couple of years.

Does anyone have experience with using the Salmonella typhi Vi
polysaccharide vaccine in this situation?

Regards,

Michael O'Sullivan

Immunology Fellow
PathWest Laboratory Medicine Western Australia /
ADx Laboratories, National Jewish Health



On 9 May 2012 15:21, Church, Joseph <JChurch at chla.usc.edu> wrote:


>  As a protein antigen, rabies vaccine will not give you the same

> information as a Pneumovax response.  Same issue with Menactra (conjugate

> meningococcal vaccine).  Menimune (non-conjugated meningococcal

> polysaccharide (4 serotype) may be helpful, but I don't know how good the

> commercial tests are.****

>

> ** **

>

> Joe Church****

>

> ** **

>

> *From:* pagid-bounces at list.clinimmsoc.org [mailto:

> pagid-bounces at list.clinimmsoc.org] *On Behalf Of *Paige Wickner

> *Sent:* Wednesday, May 09, 2012 2:15 PM

> *To:* pagid at list.clinimmsoc.org

> *Cc:* pagid at list.clinimmsoc.org

>

> *Subject:* Re: [CIS-PAGID] B-cell subset question****

>

>  ** **

>

> Agree. Rabies is a low risk vaccine. I have been vaccinated- no side

> effects experienced. ****

>

> ** **

>

> http://www.cdc.gov/vaccines/vac-gen/side-effects.htm

>

> ****

>

>

> On May 9, 2012, at 10:38 AM, "Sullivan, Kathleen" <

> sullivak at mail.med.upenn.edu> wrote:****

>

>  rabies!  It's a tough sell but also a neoantigen and it is really not so

> bad.  Two of our immunologists had bat exposures and had the vaccine and it

> had very limited side effects.****

>

> ** **

>

> Kate****

>

> On May 9, 2012, at 11:22 AM, Fleisher, Thomas (NIH/CC/DLM) [E] wrote:****

>

>

>

> ****

>

> This vaccine is not available in the US as far as I know.****

>

>  ****

>

> Thomas A. Fleisher, M.D.****

>

> Chief, Department of Laboratory Medicine****

>

> NIH Clinical Center****

>

> 301 496-5668 (T)****

>

> 301 402-1612 (F)****

>

> *From:* Seidel Markus [mailto:markus.seidel at medunigraz.at]

> *Sent:* Wednesday, May 09, 2012 11:13 AM

> *To:* pagid at list.clinimmsoc.org

> *Subject:* Re: [CIS-PAGID] B-cell subset question****

>

>  ****

>

> Dear Zach,****

>

> Tick-borne enc.(TBE)-vaccine may be used as (licensed) neo-antigen in

> order to test the B cell function under IgG substitution therapy if this

> sounds applicable… (see Seidel, Foerster-Waldl et al., 2010

> www.ncbi.nlm.nih.gov/pubmed/20656033 )****

>

> Best regards from a TBE-infested country,****

>

> Markus Seidel****

>

>  ****

>

> Markus G. Seidel, M.D., Assoc.Prof.****

>

> Consultant| Dept.of Pediatric Hematology-Oncology | Univ.Clinics of

> Pediatric and Adolescent Medicine | Auenbruggerpl. 34/2 | A-8036 Graz |

> Austria | T. 0043 316 385 80215| F. 0043 316 385 13450****

>

> Coordinator of the Working Group for Pediatric Immunology of the Austrian

> Society of Pediatrics and Adolescent Medicine****

>

>  ****

>

>  ****

>  ------------------------------

>

> *Von:* pagid-bounces at list.clinimmsoc.org [mailto:

> pagid-bounces at list.clinimmsoc.org] *Im Auftrag von *Zachary D. Jacobs, MD

> *Gesendet:* Mittwoch, 09. Mai 2012 16:13

> *An:* pagid at list.clinimmsoc.org

> *Betreff:* Re: [CIS-PAGID] B-cell subset question****

>

>  ****

>

> Thanks for the replies.  It is a challenging situation for me.  I

> inherited a large group of his patients he had on IgGRT that fit this

> general profile, probably around fifty.  The ones who didn’t think they

> ever needed to be on it were easy to trial off.  However, the majority of

> these patients have been on therapy for several years and are reluctant to

> come off.  They were told that without IVIG / SCIG they could die from an

> infection by someone who had been practicing for fifty years, and then they

> hear from me, just out of training, that they may not need it and so they

> can become skeptical.  Generally, I have tried to establish a rapport with

> the patients and a good doctor / patient relationship before broaching the

> subject of trialing off.  I have found that if I order B-cell subsets, even

> with the lack of published clinical utility for the test, if the memory

> B-cells are normal in number then the patient has something to grasp and

> feels better about trialing off therapy.  I then perform repeat antibody

> studies when they have been off for six months.****

>

>  ****

>

> Any advice on how to better deal with the situation would be much

> appreciated. ****

>

>  ****

>

> Zach****

>

>  ****

>

> On Tue, May 8, 2012 at 5:50 PM, Cunningham-Rundles, Charlotte <

> charlotte.cunningham-rundles at mssm.edu> wrote:****

>

> In my view the memory B cell phenotype can't be used in substitution of a

> complete antibody workup ( off Ig of course) .

>  I would not use the CD38+IgM or any other combination to assess antibody

> production either .

>

> Nice if we had a way around that but this is not it.

>

>

> Charlotte

>

> Charlotte Cunningham-Rundles, MD, PhD

> Departments of Medicine and Pediatrics

> The David S Gottesman Professor

> The Immunology Institute

> Mount Sinai School of Medicine

> 1425 Madison Avenue

> New York, NY 10029

> Phone: 212 659 9268

> Fax: 212 987 5593

> Email: Charlotte.Cunningham-Rundles at mssm.edu

>

>

>

> ****

>  ------------------------------

>

> *From: *"Zachary D. Jacobs, MD" <zjacobs.md at gmail.com>

> *Reply-To: *PAGID <pagid at list.clinimmsoc.org>

> *Date:*****

>

>

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