[CIS PIDD] Low CH50

[Boyce, Thomas G., M.D.]

It is not clear to me why complement levels were obtained on this pt. am I missing something?



On Jul 11, 2012, at 12:28 PM, "Santhosh Kumar/FS/VCU" <skumar at vcu.edu> wrote:


> Thank you all for the information.

>  

> She has a normal IgD and CRP level so far and she has been afebrile for a while now. She never had a consistent pattern to her fevers and not all of her febrile episodes were documented. If the febrile episodes persist, we will proceed with further workup for periodic fevers.

>  

> Santhosh Kumar, MD

> Assistant Professor,

> Allergy & Immunology

> Ph-  804-628-1605

> Fax-804-828-1751

> 

> 

> -----pagid-bounces at list.clinimmsoc.org wrote: -----

> To: "pagid at list.clinimmsoc.org" <pagid at list.clinimmsoc.org>

> From: Anita Gewurz 

> Sent by: pagid-bounces at list.clinimmsoc.org

> Date: 07/11/2012 10:31AM

> Subject: Re: [CIS PIDD] Low CH50

> 

> Dear Santhosh,

> 

> Regarding complement testing for in vitro consumption and other assays, contact:

> 

> Patricia Giclas PhD, GiclasP at NJHealth.org

> Director, Complement Laboratory

> Professor, Pediatrics Dept,  Allergy and Immunology Division

> National Jewish Medical and Research Center

> 1400 Jackson St., Denver, CO 80206  Office: M013f, BB Building

> TEL 303-398-1217

> FAX 303-270-2128

> www.njc.org/research/clinical-labs/about/learn/diaglab/complement.aspx

> 

> Your DDx should include periodic fever syndromes.  

> 

> Anita Gewurz MD

> Department of Immunology/Microbiology

> Rush University Medical Center

> Chicago IL 60612

> Tel (312) 942-6296

> Fax (312) 563-2201

> 

> From: pagid-bounces at list.clinimmsoc.org [pagid-bounces at list.clinimmsoc.org] on behalf of Santhosh Kumar/FS/VCU [skumar at vcu.edu]

> Sent: Wednesday, July 11, 2012 8:58 AM

> To: pagid at list.clinimmsoc.org

> Subject: [CIS PIDD] Low CH50

> 

> Dear All,

>  

> I have 6 y/o F who was referred to me by my ID colleague for recurrent febrile episodes since starting school. She has not had any major infections which needed hospitalization. Most of her febrile episodes were thought to be virally related. Her immune work up is normal except for low CH50 levels (repeated x 2- 12 and 15U/ml). His other classic pathway complements are normal (c2, c3, c4, c6, c7, c8,c9). AH50 is pending. I had heard of falsely low CH50 levels in past depending on the assay used. My question is:

>  

> Is this a false low CH50 level and if so is there a  better assay which can be used to confirm

>  

>  

> Thank you,

>  

> Santhosh Kumar, MD

> Assistant Professor,

> Allergy & Immunology

> Medical college of Virginia

> Ph-  804-628-1605

> Fax-804-828-1751

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