[CIS PIDD] Low CH50

[Boyce, Thomas G., M.D.]

I see.  thanks for the clarification.
 
Tom

________________________________

From: pagid-bounces at list.clinimmsoc.org
[mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Santhosh
Kumar/FS/VCU
Sent: Thursday, July 12, 2012 9:50 AM
To: pagid at list.clinimmsoc.org
Subject: Re: [CIS PIDD] Low CH50


Dear Dr.Boyce, 

You are right, there was no clear indication for complement assay in
this patient, but he was referred to me with low levels. 


Santhosh Kumar, MD 
Assistant Professor, 
Allergy & Immunology 
MCV/VCU 
Ph:804-628-1605 
Fax-804-828-1751 



From:        "Boyce, Thomas G., M.D." <Boyce.Thomas at mayo.edu> 
To:        <pagid at list.clinimmsoc.org> 
Date:        07/12/2012 10:44 AM 
Subject:        Re: [CIS PIDD] Low CH50 
Sent by:        pagid-bounces at list.clinimmsoc.org 

________________________________




It is not clear to me why complement levels were obtained on this pt. am
I missing something?



On Jul 11, 2012, at 12:28 PM, "Santhosh Kumar/FS/VCU" <skumar at vcu.edu
<mailto:skumar at vcu.edu> > wrote:

Thank you all for the information. 
  
She has a normal IgD and CRP level so far and she has been afebrile for
a while now. She never had a consistent pattern to her fevers and not
all of her febrile episodes were documented. If the febrile episodes
persist, we will proceed with further workup for periodic fevers. 
  
Santhosh Kumar, MD
Assistant Professor,
Allergy & Immunology
Ph-  804-628-1605
Fax-804-828-1751 


-----pagid-bounces at list.clinimmsoc.org wrote: ----- 
To: "pagid at list.clinimmsoc.org <mailto:pagid at list.clinimmsoc.org> "
<pagid at list.clinimmsoc.org <mailto:pagid at list.clinimmsoc.org> >
From: Anita Gewurz 
Sent by: pagid-bounces at list.clinimmsoc.org
<mailto:pagid-bounces at list.clinimmsoc.org> 
Date: 07/11/2012 10:31AM
Subject: Re: [CIS PIDD] Low CH50

Dear Santhosh, 

Regarding complement testing for in vitro consumption and other assays,
contact: 

Patricia Giclas PhD, GiclasP at NJHealth.org <mailto:GiclasP at NJHealth.org>

Director, Complement Laboratory 
Professor, Pediatrics Dept,  Allergy and Immunology Division 
National Jewish Medical and Research Center 
1400 Jackson St., Denver, CO 80206  Office: M013f, BB Building 
TEL 303-398-1217 
FAX 303-270-2128 
www.njc.org/research/clinical-labs/about/learn/diaglab/complement.aspx
<http://www.njc.org/research/clinical-labs/about/learn/diaglab/complemen
t.aspx>  

Your DDx should include periodic fever syndromes.   

Anita Gewurz MD 
Department of Immunology/Microbiology 
Rush University Medical Center 
Chicago IL 60612 
Tel (312) 942-6296 
Fax (312) 563-2201 

From: pagid-bounces at list.clinimmsoc.org
<mailto:pagid-bounces at list.clinimmsoc.org>
[pagid-bounces at list.clinimmsoc.org
<mailto:pagid-bounces at list.clinimmsoc.org> ] on behalf of Santhosh
Kumar/FS/VCU [skumar at vcu.edu <mailto:skumar at vcu.edu> ]
Sent: Wednesday, July 11, 2012 8:58 AM
To: pagid at list.clinimmsoc.org <mailto:pagid at list.clinimmsoc.org> 
Subject: [CIS PIDD] Low CH50

Dear All, 
  
I have 6 y/o F who was referred to me by my ID colleague for recurrent
febrile episodes since starting school. She has not had any major
infections which needed hospitalization. Most of her febrile episodes
were thought to be virally related. Her immune work up is normal except
for low CH50 levels (repeated x 2- 12 and 15U/ml). His other classic
pathway complements are normal (c2, c3, c4, c6, c7, c8,c9). AH50 is
pending. I had heard of falsely low CH50 levels in past depending on the
assay used. My question is: 
  
Is this a false low CH50 level and if so is there a  better assay which
can be used to confirm 
  
  
Thank you, 
  
Santhosh Kumar, MD
Assistant Professor,
Allergy & Immunology 
Medical college of Virginia
Ph-  804-628-1605
Fax-804-828-1751 

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