[CIS PIDD] Non-Hodgkin's lymphoma and AT Syndrome

[luciana Cunha]

Thank you for you help,
 we are using the course B for BFM trials for patients with chromossomal
breakage syndomes  (Annals of oncology-11 S141-145- 2000) with: dexa
10mg/m2+VCR 1,5 mg/m2+ CPM 50 mg/m2+ doxo 0,5mg/m2. We don´t have rituximab
avaiable. We usually observe severe mucositis in our patients. I will
appreciate any sugestion, Luciana.

2012/7/30 Kobrynski, Lisa <lkobryn at emory.edu>


>  We treated an AT patient for non-Hodgkin's lymphoma last year - They are

> difficult to treat and the lymphoma tends to be agressive with rapid

> metastases.  We used the standard chemotherapy protocol, including

> rituximab, minus any irradiation.  The patient continued to receive IVIG

> and we tried to keep his IgG levels high (900-1000). He actually did not

> develop severe mucositis so I can not comment about lasertherapy.

>

> We initially appeared to have good success with regression of the tumor on

> PET scan, however, he had complications from EBV infection.

>

>

>  Lisa Kobrynski, MD, MPH

> Associate Professor of Pediatrics

> Marcus Professor of Immunology

> Section, Allergy/Immunology

>   ------------------------------

> *From:* pagid-bounces at list.clinimmsoc.org [

> pagid-bounces at list.clinimmsoc.org] on behalf of luciana Cunha [

> lucianaaoc at gmail.com]

> *Sent:* Monday, July 30, 2012 10:08 AM

>

> *To:* pagid at list.clinimmsoc.org

> *Subject:* [CIS PIDD] Non-Hodgkin's lymphoma and AT Syndrome

>

>  Dears friends and colleagues:

> I would like to know if somebody has experience with chemoterapy for

> non-Hodgkin's lymphoma in A-T Syndrome.

> We have a 5 years old girl with A-T syndrome and non-Hodkin's lymphoma. We

> are very unsecure about the intensity of chemotherapy regimen. We also like

> to know if should we use prophylatic lasertherapy to prevent oral

> mucositis. Thank you very much, Luciana.

>

>

>

> Luciana A. O. Cunha

> Federal University of Minas Gerais

> Brazil

>

>

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