[CIS PIDD] Non-Hodgkin's lymphoma and AT Syndrome

[Kobrynski, Lisa]

We treated an AT patient for non-Hodgkin's lymphoma last year - They are difficult to treat and the lymphoma tends to be agressive with rapid metastases.  We used the standard chemotherapy protocol, including rituximab, minus any irradiation.  The patient continued to receive IVIG and we tried to keep his IgG levels high (900-1000). He actually did not develop severe mucositis so I can not comment about lasertherapy.

We initially appeared to have good success with regression of the tumor on PET scan, however, he had complications from EBV infection.



Lisa Kobrynski, MD, MPH
Associate Professor of Pediatrics
Marcus Professor of Immunology
Section, Allergy/Immunology
________________________________
From: pagid-bounces at list.clinimmsoc.org [pagid-bounces at list.clinimmsoc.org] on behalf of luciana Cunha [lucianaaoc at gmail.com]
Sent: Monday, July 30, 2012 10:08 AM
To: pagid at list.clinimmsoc.org
Subject: [CIS PIDD] Non-Hodgkin's lymphoma and AT Syndrome

Dears friends and colleagues:
I would like to know if somebody has experience with chemoterapy for non-Hodgkin's lymphoma in A-T Syndrome.
We have a 5 years old girl with A-T syndrome and non-Hodkin's lymphoma. We are very unsecure about the intensity of chemotherapy regimen. We also like to know if should we use prophylatic lasertherapy to prevent oral mucositis. Thank you very much, Luciana.



Luciana A. O. Cunha
Federal University of Minas Gerais
Brazil


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