[CIS PIDD] Warts and T-cell lymphopenia

[Bodo Grimbacher]

We do Dock8 on a research basis at the CCI in Freiburg, Germany.
But we screen with PCR on genomic DNA and with Western, so we ask for gDNA
and protein/blood.
Best, Bodo

****************************************
Univ.-Prof. Dr. med. B. Grimbacher
Scientific Director
CCI - Centre of Chronic Immunodeficiency
UNIVERSITÄTSKLINIKUM FREIBURG
Tel.: 0761 270-77731  Fax: -77732
Engesserstraße 4, 79108 Freiburg
bodo.grimbacher at uniklinik-freiburg.de
http://www.uniklinik-freiburg.de/cci









Am 07.08.12 22:41 schrieb "Kirkpatrick, Charles" unter
<Charles.Kirkpatrick at ucdenver.edu>:


>Thanks, Tom.  I have been concerned about DOCK8 in this man.  His IgE is

>normal. Who  does the genetic study?

> 

>Chuck

> 

>From: pagid-bounces at list.clinimmsoc.org

>[mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Fleisher, Thomas

>(NIH/CC/DLM) [E]

>Sent: Tuesday, August 07, 2012 8:40 AM

>To: 'pagid at list.clinimmsoc.org'

>Subject: Re: [CIS PIDD] Warts and T-cell lymphopenia

>

>

> 

>? DOCK8 

>--------------------------

>Dr. Thomas Fleisher

>Department of Laboratory Medicine

>National Institutes of Health

>Phone: (301) 496-5668

> 

>From: Kirkpatrick, Charles [mailto:Charles.Kirkpatrick at ucdenver.edu]

>Sent: Tuesday, August 07, 2012 10:35 AM

>To: 'pagid at list.clinimmsoc.org' <pagid at list.clinimmsoc.org>

>Subject: [CIS PIDD] Warts and T-cell lymphopenia

> 

>

>I am evaluating a 48 y/o Caucasian male who developed extensive warts on

>his hands and feet  about 1998 but spreading widely over feet and hands

>since 2003.  He was well until then, but he had a cutaneous VZV infection

>shortly before the onset of warts.  There have been no genital lesions.

>Failed treatments include liquid nitrogen, Aldara, topical sensitization

>and application of 2% and 4% CDNB, intralesional injections of Candida

>skin test antigen, V-Beam laser treatments, duct tape and many herbal and

>OTC medications.

> 

>Labs:  HIV ­ negative X2, CBC normal, IgG, IgA, IgM all normal, absolute

>CD3 ­ 260/ul; CD4 190/ul; CD8 ­ 60/ul; CD45/CD4 RA 2.3% of total T-cells

>(control 57.7%); CD45/CD4/RO -96.8% of total T-cells (control 40.8%).

>T-cell proliferations to PHA, ConA and PWM all low; proliferation

>response to tetanus ­ low; to Candida normal.  DTH to Candida 28 mm

>induration.

> 

>Any comments about diagnosis?  Does anyone have experience with topical

>or intravenous Cidifovir in patients such as this?

> 

>All comments appreciated.

> 

>Charles Kirkpatrick, M.D.

>Allergy and Immunology

>University of Colorado Health Sciences Center