[CIS PIDD] CGD and cutaneous ulcers

[Michael H. Land, MD]

Dear Sara,

At the UCLA Medical Center where I trained, my mentors Dr. Richard Stiehm and Dr. Robert Roberts have been treating patients with topical GM-CSF for over a decade and have published this.  I am sure they would be approachable and interested in sharing their more recent experience.  One of their papers from 2002 is the following, if you have not already seen it:

De Ugarte DA, Roberts RL, Lerdluedeeporn P, Stiehm ER, Atkinson JB.  Treatment of chronic wounds by local delivery of granulocyte-macrophage colony-stimulating factor in patients with neutrophil dysfunction. Pediatr Surg Int. 2002 Sept; 18(5-6): 517-20.

At Duke University Medical Center we have also been treating some PIDD patients with topical GM-CSF as well, which has helped greatly (particularly in one patient with a peri-rectal ulcer that was very difficult to treat).  It is an expensive therapy, but has been an important tool.

Best regards,
Michael


Michael H.
Land, MD FAAAAI
Assistant
Professor of Pediatrics
Department
of Pediatrics, Division of Allergy & Immunology
Duke University Medical Center, Box 2644
Durham, NC 27710
Phone: 919-862-5354 or for Patient Issues: 919-684-9914
Fax: 919-862-5355
Email: m.land at duke.edu


________________________________
 From: "Leo, Sara" <sleo at cw.bc.ca>
To: "pagid at list.clinimmsoc.org" <pagid at list.clinimmsoc.org> 
Sent: Friday, August 10, 2012 5:18 PM
Subject: [CIS PIDD] CGD and cutaneous ulcers
 

 
Dear Colleagues,

My name is Sara Leo and I'm a 2nd year Pediatric Immunology/Allergy fellow at BC Children's Hospital in Vancouver, BC. About a year ago, Dr. Stuart Turvey wrote to PAGID to see if anyone had experience with using topical GM-CSF to treat CGD patients with cutaneous
 ulcers. Since then, we have successfully treated our patient with topical GM-CSF. We would like to put together a case series of CGD patients with cutaneous ulcers that have been treated with topical GM-CSF and would be interested in hearing about both failed
 and successful regimens. If anyone has experience with the above and would like to collaborate with us, we would love to hear from you.

Yours Sincerely,
Sara 
 
Sara Leo BSc, MD, FRCPC
Pediatric Clinical Immunology and Allergy, PGY-5
University of British Columbia
BC Children's Hospital
Email: sleo at cw.bc.ca
Pager: 410-1447 
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