[CIS PIDD] CGD and cutaneous ulcers

[Richard Wasserman]

You might consider granulocyte transfusions. If you do, I'd apply G-CSF,
GM-CSF, or Regranex (PDGF) http://www.regranex.com/PI_Full_Version.pdf about
30 minutes prior to the transfusion.
Richard Wasserman
Dallas

On Sat, Aug 11, 2012 at 2:37 PM, Michael H. Land, MD
<mikelandmd at yahoo.com>wrote:


> Dear Sara,

>

> At the UCLA Medical Center where I trained, my mentors Dr. Richard Stiehm

> and Dr. Robert Roberts have been treating patients with topical GM-CSF for

> over a decade and have published this.  I am sure they would be

> approachable and interested in sharing their more recent experience.  One

> of their papers from 2002 is the following, if you have not already seen it:

>

> De Ugarte DA, Roberts RL, Lerdluedeeporn P, Stiehm ER, Atkinson JB.

> Treatment of chronic wounds by local delivery of granulocyte-macrophage

> colony-stimulating factor in patients with neutrophil dysfunction. Pediatr

> Surg Int. 2002 Sept; 18(5-6): 517-20.

>

> At Duke University Medical Center we have also been treating some PIDD

> patients with topical GM-CSF as well, which has helped greatly

> (particularly in one patient with a peri-rectal ulcer that was very

> difficult to treat).  It is an expensive therapy, but has been an important

> tool.

>

> Best regards,

> Michael

>

> Michael H. Land, MD FAAAAI

> Assistant Professor of Pediatrics

> Department of Pediatrics, Division of Allergy & Immunology

> Duke University Medical Center, Box 2644

> Durham, NC 27710

> Phone: 919-862-5354 or for Patient Issues: 919-684-9914

> Fax: 919-862-5355

> Email: m.land at duke.edu

>

>   ------------------------------

> *From:* "Leo, Sara" <sleo at cw.bc.ca>

> *To:* "pagid at list.clinimmsoc.org" <pagid at list.clinimmsoc.org>

> *Sent:* Friday, August 10, 2012 5:18 PM

> *Subject:* [CIS PIDD] CGD and cutaneous ulcers

>

>   Dear Colleagues,

>

> My name is Sara Leo and I'm a 2nd year Pediatric Immunology/Allergy fellow

> at BC Children's Hospital in Vancouver, BC. About a year ago, Dr. Stuart

> Turvey wrote to PAGID to see if anyone had experience with using topical

> GM-CSF to treat CGD patients with cutaneous ulcers. Since then, we have

> successfully treated our patient with topical GM-CSF. We would like to put

> together a case series of CGD patients with cutaneous ulcers that have been

> treated with topical GM-CSF and would be interested in hearing about both

> failed and successful regimens. If anyone has experience with the above and

> would like to collaborate with us, we would love to hear from you.

>

> Yours Sincerely,

> Sara

>

>   Sara Leo BSc, MD, FRCPC

> Pediatric Clinical Immunology and Allergy, PGY-5

> University of British Columbia

> BC Children's Hospital

> Email: sleo at cw.bc.ca

> Pager: 410-1447

>

>

>



-- 
Richard L. Wasserman, MD, PhD
DallasAllergyImmunology
7777 Forest Lane, Suite B-332
Dallas, Texas 75230
Office (972) 566-7788
Fax (972) 566-8837
Cell (214) 697-7211
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