[CIS PIDD] [cis-pidd] Bone marrow transplant for X-linked CGD

[Prof. Dr. Antonio Condino Neto]

I would try gene therapy for CGD

Contact Thrasher in London
-- 
Antonio Condino-Neto
Professor of Experimental Medicine
Institute of Biomedical Sciences, University of São Paulo
1730 Lineu Prestes Avenue, São Paulo - SP. ZIP 05508-000. Brazil
Tel (55) (11) 3091-7387 / Fax (55) (11) 3091-7224



Citando "Newburger, Peter" <Peter.Newburger at umassmed.edu>:


> I can't comment on the donor/HSCT issues, but would suggest that you  

> evaluate and possibly treat the patient for secondary HLH prior to  

> transplant.

> Regards,

> Peter Newburger

> -------------------------------------------------------------

> Peter E. Newburger, MD

> Ali and John Pierce Professor of

>      Pediatric Hematology/Oncology

> Vice Chair for Research

> Department of Pediatrics

> University of Massachusetts Medical School

> 55 Lake Avenue North

> Worcester, MA 01655

> tel. 508 856-4225

> fax 508 856-4282

> peter.newburger at umassmed.edu<mailto:peter.newburger at umassmed.edu>

> -------------------------------------------------------------

>

> ________________________________

> From: Howard Lederman [hlederm1 at jhmi.edu]

> Sent: Thursday, October 18, 2012 2:00 PM

> To: CIS-PIDD

> Subject: [cis-pidd] Bone marrow transplant for X-linked CGD

>

> We have a 4 y/o boy with X-linked CGD who has had a stormy course  

> with a history of multiple infections  and mild inflammatory bowel  

> disease.  He currently has  generalized adenopathy,  

> hepatosplenomegaly and bone marrow granulomas without an  

> identifiable microbial cause.  He has not responded to a variety of  

> antibiotics, but is improving with  corticosteroids. We would like  

> to do a bone marrow transplant.

>

> The available donor options are:

>

>

> 1.       Unrelated  4/6 matched cord blood (match at DRB1)

>

> 2.       Haploidentical parent (probably the father, as the mother  

> has a mixed connective tissue disease)

>

> 3.       One possible NMDP unrelated donor who is mismatched at A

>

> I am interested in the experience of others with donor choice.  I am  

> also interested in recommendations for full myeloablation  vs.  

> reduced intensity conditioning, particularly in view of the recent  

> publication from Duke (Tewari et al 2012.  Biol Blood Marrow  

> Transplant 18:1368-77).

>

>

> Howard M. Lederman, M.D., Ph.D.

> Professor of Pediatrics, Medicine and Pathology Division of  

> Pediatric Allergy and Immunology Johns Hopkins Hospital - CMSC 1102  

> 600 N. Wolfe Street Baltimore, MD 21287-3923

> Phone: 410-955-5883

> Fax: 410-955-0229

> Email: Hlederm1 at jhmi.edu<mailto:Hlederm1 at jhmi.edu>

>

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