[CIS PIDD] [cis-pidd] Memory B-cells & switched memory B-cells in Antibody deficiency patients

[Stan Ress]

Dear colleagues,
 
Aside from their value in classifying CVH patients, there are
references to measuring memory B-cells in other patients with diverse
antibody deficiencies, as being a better prognostic indicator of
susceptibility to infections than absolute Ig levels. Do people
routinely make use of these B-cell markers to monitor patients and/or
decide on IVIG where the indication may not be so clear cut, & if so,
what B-cell subsets are being requested: 

Memory B-cells (CD27+ IgM+ IgD-) &  Isotype switched memory B-cells
(CD27+IgM-IgD-)? Would you also routinely request the % of switched
memory B-cells according to CD21 expression, for example in a patient
with isolated, mildly reduced IgG ? Or would you reserve the latter only
for CVH patients?
 
As I'm trying to set up this B-cell panel for use in managing my
patients, I'd value comments & suggestions.
 
Thanks,
 
Stan



 
 
--
Stanley Ress
Associate Professor of Medicine
Head: Division of Clinical Immunology
Department of Medicine
H47 Old Main Building-room 26
Groote Schuur Hospital and UCT
Observatory 7925
Cape Town
South Africa
TEL:INTERN. + 2721-4066201 or 4066197
FAX:   "    + 2721-4486815
Cell: 0833115482 
email: stan.ress at uct.ac.za




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