[CIS PIDD] [cis-pidd] Memory B-cells & switched memory B-cells in Antibody deficiency patients

[Cunningham-Rundles, Charlotte]

In my view, there is no substitute for testing a range of antibodies in the blood.  After all, other diseases include low isotype switched  memory B cells and yet we do not use Ig replacement unless there is  loss of antibody.

Charlotte Cunningham-Rundles MD PhD


On 11/29/12 8:59 AM, "Stan Ress" <Stan.Ress at uct.ac.za> wrote:

Dear colleagues,



Aside from their value in classifying CVH patients, there are references to measuring memory B-cells in other patients with diverse antibody deficiencies, as being a better prognostic indicator of susceptibility to infections than absolute Ig levels. Do people routinely make use of these B-cell markers to monitor patients and/or decide on IVIG where the indication may not be so clear cut, & if so, what B-cell subsets are being requested:

Memory B-cells (CD27+ IgM+ IgD-) &  Isotype switched memory B-cells (CD27+IgM-IgD-)? Would you also routinely request the % of switched memory B-cells according to CD21 expression, for example in a patient with isolated, mildly reduced IgG ? Or would you reserve the latter only for CVH patients?

As I'm trying to set up this B-cell panel for use in managing my patients, I'd value comments & suggestions.

Thanks,

Stan





--
Stanley Ress
Associate Professor of Medicine
Head: Division of Clinical Immunology
Department of Medicine
H47 Old Main Building-room 26
Groote Schuur Hospital and UCT
Observatory 7925
Cape Town
South Africa
TEL:INTERN. + 2721-4066201 or 4066197
FAX:   "    + 2721-4486815
Cell: 0833115482
email: stan.ress at uct.ac.za



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