[CIS PIDD] [cis-pidd] Memory B-cells & switched memory B-cells in Antibody deficiency patients

[Routes, John]

totally agree with Charlotte

John M. Routes, MD
Chief, Section of Allergy and Clinical Immunology
Co-Director, Clinical and Translational Science Institute of Southeast WI
Professor of Pediatrics, Medicine, Microbiology and Molecular Genetics
Department of Pediatrics
Children's Hospital of Wisconsin
Medical College of Wisconsin
9000 W. Wisconsin Ave.
Milwaukee, WI  53226-4874

Phone: 414-266-6840 (Administrative Assistant)
Phone: 414-456-4802 (Office)
Fax: 414-456-6487 (Clinical)
Fax: 414-456-6323 (Laboratory)
Email: jroutes at mcw.edu




________________________________
From: Stan Ress <Stan.Ress at uct.ac.za>
Reply-To: CLINICAL IMMUNOLOGY LISTSERV <cis-pidd at lists.clinimmsoc.org>
Date: Thu, 29 Nov 2012 15:59:27 +0200
To: CLINICAL IMMUNOLOGY LISTSERV <cis-pidd at lists.clinimmsoc.org>
Subject: [cis-pidd] Memory  B-cells & switched memory B-cells in Antibody deficiency patients

Dear colleagues,



Aside from their value in classifying CVH patients, there are references to measuring memory B-cells in other patients with diverse antibody deficiencies, as being a better prognostic indicator of susceptibility to infections than absolute Ig levels. Do people routinely make use of these B-cell markers to monitor patients and/or decide on IVIG where the indication may not be so clear cut, & if so, what B-cell subsets are being requested:

Memory B-cells (CD27+ IgM+ IgD-) &  Isotype switched memory B-cells (CD27+IgM-IgD-)? Would you also routinely request the % of switched memory B-cells according to CD21 expression, for example in a patient with isolated, mildly reduced IgG ? Or would you reserve the latter only for CVH patients?

As I'm trying to set up this B-cell panel for use in managing my patients, I'd value comments & suggestions.

Thanks,

Stan





--
Stanley Ress
Associate Professor of Medicine
Head: Division of Clinical Immunology
Department of Medicine
H47 Old Main Building-room 26
Groote Schuur Hospital and UCT
Observatory 7925
Cape Town
South Africa
TEL:INTERN. + 2721-4066201 or 4066197
FAX:   "    + 2721-4486815
Cell: 0833115482
email: stan.ress at uct.ac.za



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