[CIS PIDD] [cis-pidd] Fwd: Hyper IgE syndrome

[Nacho Gonzalez]

I would add amikacin or gentamycin to cefepime for pseudomonas. If staph is
susceptible I would switch as soon as posible to cloxacillin. Perhaps ivig
might help. no experience with omalizumab,but i would be reluctant to use
it,at least in this acute phase.

Best regards

Luis I. Gonzalez Granado
Pediatrics. Immunodeficiencies
Hospital 12 octubre. Madrid. Spain
El 29/03/2013 00:45, "luciana Cunha" <lucianaaoc at gmail.com> escribió:


>

> Dear friends:

>

> I would like to discuss a case.

> We admitted at ICU a 7 year-old girl who was being treated as a severe

> atopic dermatitis, presenting with a staphylococcal and pseudomonas sepsis.

> She also has eosinophilia (>2000/mL), normal immunoglobulins levels,

> normal lymphocyte immunophenotyping ( CD3,CD4, CD8 CD19, CD16/56), primary

> teeth retention, chronic eczema, characteristic face and high palate. She

> doesn't present pneumonias or parenchimal lung anomalies. She is from a

> consanguinous family with many cases of less severe atopic dermatitis.

> At the moment, she is using vancomycin, cefepime, prednisone 1mg/kg/day

> and diphenydramine. We are considering the use of gammaglobulin or

> omalyzumab. What's your opinion? Any other suggestion?

> Thank you very much,

>

> Luciana Cunha

> Primary Immunodeficiency Service

> Federal University of Minas Gerais

> Brazil

>

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