[CIS PIDD] [cis-pidd] current opinions on live vaccines and DiGeorge Syndrome

[Sullivan, Kathleen]

Good to go- everyone's counts go down at some point.
On Apr 1, 2013, at 9:29 PM, Joyce Yu wrote:


> Hi all,

>  

> I'm taking care of a 1.5 yo boy with DiGeorge Syndrome and have been asked whether he can get the live vaccines.

>  

> He has otherwise been generally well (aside from his cardiac and feeding issues).

>  

> Most recent testing showed: 

> CD4 859 (1204 at prior testing)

> CD8 721 (1921 prior)

> NK 415 (757 prior)

> CD19 2182 (3534 prior)

>  

> He has normal response to PHA, ConA, and slightly decreased response to PWM. He also has NL IgG, IgM, IgA and protective titers to diphtheria, tetanus, Hib, and pneumococcal (+ titers to 8 of 14)

>  

> Since he appears to have decent T and B cell function, I am thinking that he has little risk for receiving the MMR and varicella. However, his lymphocyte counts have decreased in the past year or so, so I am not sure whether I should take that into consideration. I was wondering whether anyone has looked further into the issue of cutoffs for lymphocyte counts, or could I make my decision based on functional studies despite decreasing absolute number of lymphocytes?

>  

> Thanks,

>  

> Joyce Yu

> Weill Cornell Medical Center

> ---

> 

> The CIS-PIDD listserv is supported by:

> 

> 

> The science & practice of human immunology

> 

> P: +1.414.224.8095

> E: info at clinimmsoc.org

> 

> Not a member of CIS? Please visit www.clinimmsoc.org to join!

> 

> You are currently subscribed to cis-pidd as: sullivak at mail.med.upenn.edu.

> To unsubscribe click here: http://lm.clinimmsoc.org/u?id=183824771.d123d252090ca5b0b32c510b919da279&n=T&l=cis-pidd&o=43073700

> 


Kate Sullivan, MD PhD
Professor of Pediatrics
ARC 1216 Immunology CHOP
3615 Civic Center Blvd.
Philadelphia, PA 19104
(p) 215-590-1697
(f) 267-426-0363



---
The CIS-PIDD listserv is supported by the Clinical Immunology Society
The science & practice of human immunology

P: +1.414.224.8095
E: info at clinimmsoc.org

Not a member of CIS? Please visit www.clinimmsoc.org to join!

You are currently subscribed to cis-pidd as: pagid at list.clinimmsoc.org.
To unsubscribe click here: http://lm.clinimmsoc.org/u?id=183939985.3ea13d40a15475ac00ebbd9cd8a37d6d&n=T&l=cis-pidd&o=43075775
or send a blank email to leave-43075775-183939985.3ea13d40a15475ac00ebbd9cd8a37d6d at lists.clinimmsoc.org
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://seven.pairlist.net/pipermail/pagid/attachments/20130402/02e016b7/attachment-0001.html>