[CIS PIDD] [cis-pidd] MYD88

[Torgerson, Troy]

Howard,

I'm not sure if anyone is offering sequencing in a CLIA lab but there are at least 2 labs doing TLR testing where patient cells are stimulated with TLR ligands and the readout is cytokine production - these should detect most MYD88/IRAK4 defects.  ARUP has a TLR functional assay that tests TLR's 1-8 and looks at production of IL-1, TNF, and IL–6.  The TLR3 results on the ARUP test can be a little variable but the rest of them seem to be pretty reliable. IDT labs also does it but measures production of only 1 cytokine.  National Jewish was also offering a TLR screen but I don't see it on their test menu now.

Best,
Troy


Troy R. Torgerson, MD PhD

Assistant Professor, Pediatric Immunology/Rheumatology
Director, Immunology Diagnostic Laboratory (IDL)
University of Washington and Seattle Children's Hospital

Address:
Seattle Children's Research Institute
1900 9th Ave., C9S-7
Seattle, WA  98101-1304

Tel:  (206) 987-7317
Fax:  (206) 987-7310

IDL Tel:  (206) 987-7IDL (-7435)
Web:  www.seattlechildrens.org/IDL


From: Howard Lederman <hlederm1 at jhmi.edu<mailto:hlederm1 at jhmi.edu>>
Reply-To: CIS-PIDD <cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>>
Date: Tuesday, April 30, 2013 12:43 PM
To: CIS-PIDD <cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>>
Subject: [cis-pidd] MYD88

Does anyone know a commercial (or other lab) that will sequence MYD88, or a commercial lab that can do a functional test for IRAK4/MYD88?

Howard
Howard M. Lederman, M.D., Ph.D.
Professor of Pediatrics, Medicine and Pathology Division of Pediatric Allergy and Immunology Johns Hopkins Hospital - CMSC 1102 600 N. Wolfe Street Baltimore, MD 21287-3923
Phone: 410-955-5883
Fax: 410-955-0229
Email: Hlederm1 at jhmi.edu<mailto:Hlederm1 at jhmi.edu>

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