[CIS PIDD] [cis-pidd] DiGeorge and live virus vaccines

[Boyce, Thomas G., M.D.]

I think Kate Sullivan has some data on this but as I recall it was more of a case series.  I think she uses a CD8 cut off of 300 but I could be wrong.


Thomas G. Boyce, MD, MPH
Pediatric Infectious Diseases and Immunology
Mayo Clinic
email: boyce.thomas at mayo.edu
phone: 507-255-8464
fax: 507-255-7767


From: bounce-43691863-183824398 at lists.clinimmsoc.org [mailto:bounce-43691863-183824398 at lists.clinimmsoc.org] On Behalf Of Verbsky, James
Sent: Friday, August 09, 2013 1:07 PM
To: CIS-PIDD
Subject: RE:[cis-pidd] DiGeorge and live virus vaccines

Not sure we have any evidence for this...but we usually like to see a normal mitgens..then give varivax first since there is a treatment for any complications with this virus.  Would be interested in what others do?

Best

James


James W. Verbsky M.D./Ph.D.
Associate Professor of Pediatrics and Microbiology
Medical College of Wisconsin
Milwaukee, WI
414-266-6701



From: Haines, Kathleen M.D. [mailto:KHaines at HackensackUMC.org]
Sent: Friday, August 09, 2013 1:01 PM
To: CIS-PIDD
Subject: [cis-pidd] DiGeorge and live virus vaccines

I have a 2yo girl w/DiGeorge due/overdue for live virus vaccines.  She is in good health.  However her lymphocyte subsets are as follows:  WBC 2500; CD3 707; CD4 483; CD8 217; CD 56/16 178.  She has made good antibodies to tetanus and responded to 5/7 pneumococcal subtypes in Prevnar.   Overall Igs: IgG 615 mg/dL; IgA 18 mg/dL; IgM 35 mg/dL.  I haven't done any lymphocyte functions.

I'm usually happy to give the live vaccines when the CD8 is close to 300 without any functional tests.  Should I go ahead and vaccinate w/ MMRV or hold off?  Opinions?

Kathleen A. Haines, MD
Section Chief, Pediatric Immunology
Section of Pediatric Rheumatology & Immunology
Hackensack UMC
30 Prospect Ave.
Hackensack, NJ 07601

Tel: 551-996-5306
Fax: 201-996-9815
khaines at HackensackUMC.org<mailto:khaines at HackensackUMC.org>

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