[CIS PIDD] [cis-pidd] Positive NB Screen

[Richard Wasserman]

Jack,
Family and personal history are negative. Physical is normal, no thrush,
normal palate, normal cardiac exam. Anything beyond CD45RA/RO with the next
draw?
Thanks,
Richard


On Fri, Sep 6, 2013 at 3:54 PM, Routes, John <jroutes at mcw.edu> wrote:


> Richard

> you need to get the percentage of naive and memory T cells with the next

> draw--is the history and PE normal?

> Jack

>

>

>

> John M. Routes, MD

> Chief, Section of Allergy and Clinical Immunology

> Professor of Pediatrics, Medicine, Microbiology and Molecular Genetics

> Department of Pediatrics

> Children's Hospital of Wisconsin

> Medical College of Wisconsin

> 9000 W. Wisconsin Ave.

> Milwaukee, WI  53226-4874

> Phone: Office 414-266-6840

> Fax: 414-456-6487 (Clinical)

> Fax: 414-456-6323 (Laboratory)

> Email: jroutes at mcw.edu<mailto:jroutes at mcw.edu>

>

>

>

>

>

> On Sep 6, 2013, at 4:08 PM, Richard Wasserman <drrichwasserman at gmail.com

> <mailto:drrichwasserman at gmail.com>>

>  wrote:

>

> The data shown are all that I have to date. I am trying to be parsimonious

> in the phlebotomies and wanted some input before drawing more lab.

> Richard

>

>

> On Fri, Sep 6, 2013 at 2:40 PM, Harville, Terry O <HarvilleTerryO at uams.edu

> <mailto:HarvilleTerryO at uams.edu>> wrote:

> Richard,

>

> We see values like this in the Partial DiGeorge setting.

>

> Were CD45RO and CD45RA evaluated?

>

> Terry Harville MD PhD

> -Medical Director, Special Immunology Laboratory

> -Medical Director, Histocompatibility Laboratory

> -Medical Director, Immunogenetics and Transplantation Laboratory

> -Specialist in Pediatric Immunology and Rheumatology

> Departments of Pathology and Laboratory Services and Pediatrics

> University of Arkansas for Medical Sciences

> 4301 West Markham

> Mail Slot #502

> Little Rock, AR  72205-7199

>

> Work Phone

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> 501.686.7257<tel:501.686.7257>

> Work Phone

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> Work Phone

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> 501.686.7556<tel:501.686.7556>

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> 501.364.1885<tel:501.364.1885>

> Work Fax

> 1..........................................................................

> 501.686.7443<tel:501.686.7443>

> Work Fax

> 2..........................................................................501.526.4621<tel:501.526.4621>

>

>

> Email..............................................................harvilleterryo at uams.edu

> <mailto:

> Email..............................................................harvilleterryo at uams.edu

> >

>

> Special Immunology

> Laboratory......................................501.364.1804<tel:501.364.1804>

> Histocompatibility

> Laboratory..........................................501.686.7257<tel:501.686.7257>

> Immunogenetics and Transplantation

> Laboratory.........501.686.7374<tel:501.686.7374>

>

> From: Richard Wasserman [mailto:drrichwasserman at gmail.com<mailto:

> drrichwasserman at gmail.com>]

> Sent: Friday, September 06, 2013 2:20 PM

> To: CIS-PIDD

> Subject: [cis-pidd] Positive NB Screen

>

> I have been evaluating a normal term female with an abnormal SCID screen

> of "very low TRECs". The available data are below:

>

> Day of life 38

>

> Day of life 62

>

> Abs.CD19+ Lymphs L 544 (/uL) 600-1900 01

> Absolute CD 3 L 718 (/uL) 2300-7000 01

> Absolute CD 4 Helper L 538 (/uL) 1700-5300 01

> Abs. CD 8 Suppressor L 178 (/uL) 400-1700 01

> Ab NK (CD56/16) 482 (/uL) 200-1400 01

> WBC L 3.9 (x10E3/uL) 5.0-12.4 01

>

> Abs.CD19+ Lymphs 1059 (/uL) 600-1900 01

> Absolute CD 3 L 957 (/uL) 2300-7000 01

> Absolute CD 4 Helper L 682 (/uL) 1700-5300 01

> Abs. CD 8 Suppressor L 267 (/uL) 400-1700 01

> Ab NK (CD56/16) 795 (/uL) 200-1400 01

> WBC 5.1 (x10E3/uL) 5.0-12.4

>

> Day of life 25 PHA = 47%, IgM = 10ml/dL

>

> PHA day of life 47 = 111%

>

> Adenosine deaminase 15.02

>

>

>

>

> She has been well. As you can see, her PHA normalized and her counts are

> improving. I'd appreciate suggestions for further evaluation.

>

> Richard Wasserman

> Dallas

> --

> Richard L. Wasserman, MD, PhD

> DallasAllergyImmunology

> 7777 Forest Lane, Suite B-332

> Dallas, Texas 75230

> Office (972) 566-7788<tel:%28972%29%20566-7788>

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> --

> Richard L. Wasserman, MD, PhD

> DallasAllergyImmunology

> 7777 Forest Lane, Suite B-332

> Dallas, Texas 75230

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-- 
Richard L. Wasserman, MD, PhD
DallasAllergyImmunology
7777 Forest Lane, Suite B-332
Dallas, Texas 75230
Office (972) 566-7788
Fax (972) 566-8837
Cell (214) 697-7211

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