[CIS PIDD] [cis-pidd] Liver Transplant in patient with Common Variable Immunodeficiency

[Richard Wasserman]

John,

In the late 80's I picked up an XLA in his late 30's with liver failure due
to hepatitis C. There was considerable discussion with the transplant
committee about transplanting someone with immunodeficiency. He was
transplanted and did rather well. Over the 15 years before he died of
chronic rejection, he experienced and recovered from aspergillus brain
abscess and a replapse of Echo 11 encephalitis. He worked full time as an
engineer and traveled the world, saw his children grow up and graduate from
college. Not a terrible outcome. Not strictly comparable to CVID because he
didn't have the same problems with dysregulation that your patient has had.
Richard


On Fri, Sep 27, 2013 at 7:08 AM, Sullivan, John (Office of Research) <
John.Sullivan at umassmed.edu> wrote:


>  Colleagues, I have a 42 yo male with CVID that I diagnosed 30 years ago.

> He developed hepatopulmonary syndrome secondary to granulomatous hepatitis.

> Otherwise he has done very well. He is oxygen dependent and the

> pulmonologists say that a liver transplant will fix his lungs but the

> transplant people are reluctant because of his CVID. I say do transplant as

> he has done very well escaping serious infections with his IVIG. I would

> appreciate hearing your experiences with liver transplantation in patients

> with CVID.  John.

>

>

>   John L. Sullivan, M.D.

>  Program in Molecular Medicine

>  University of Massachusetts Medical School

>  373 Plantation St, Suite 210

> Worcester, MA 01605

> 508-856-1638

> John.sullivan at umassmed.edu

>

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-- 
Richard L. Wasserman, MD, PhD
DallasAllergyImmunology
7777 Forest Lane, Suite B-332
Dallas, Texas 75230
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