[CIS PIDD] [cis-pidd] Persitently elevated EBV IgM

[Sullivan, Kathleen]

IgM can persist for awhile but the real red flag is if they have viremia for more than 3 months or fail to convert to EBNA positive.  Then you want to think of some of the single gene defects identified recently:


•SH2D1A
•XIAP
•ITK
•MAGT1
•PKCd
•Coronin 1A
•CD27

Kate
On Oct 9, 2013, at 4:39 PM, Jason Raasch wrote:


> Appreciate your thoughts/opinions:

>  

> In a patient (any age) who's basic immune evaluation for recurrent respiratory illness is unremarkable, how convinced are you that a persistently positive EBV VCA IgM (in the presence of EBV VCA IgG +/- EBNA) indicates chronic EBV infection or carrier status?  What if EBV PCR from peripheral blood is negative?

>  

> In other words, in your experience what is the SPECIFICITY of a persistently positive EBV VCA IgM ?  Are there some individuals who just never down-regulate EBV VCA IgM expression?

>  

> Thanks for your thoughts.

>  

> -Jason

> 

>  

> 

> Jason Raasch, MD

> 

> Midwest Immunology Clinic

> 15700 37th Ave N, Ste 110

> Plymouth, MN 55446

> 

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Kate Sullivan, MD PhD
Professor of Pediatrics
ARC 1216 Immunology CHOP
3615 Civic Center Blvd.
Philadelphia, PA 19104
(p) 215-590-1697
(f) 267-426-0363



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