[CIS PIDD] [cis-pidd] Persitently elevated EBV IgM

[Church, Joseph]

The failure to convert to EBNA+ was also common in the pre-HAART days of HIV.

Also, regarding the "negative blood PCR" was this done on whole blood(preferred) or plasma?

Joe Church
Children's Hospital Los Angeles

From: Sullivan, Kathleen [mailto:sullivak at mail.med.upenn.edu]
Sent: Wednesday, October 09, 2013 1:50 PM
To: CIS-PIDD
Subject: Re: [cis-pidd] Persitently elevated EBV IgM

IgM can persist for awhile but the real red flag is if they have viremia for more than 3 months or fail to convert to EBNA positive.  Then you want to think of some of the single gene defects identified recently:


*SH2D1A
*XIAP
*ITK
*MAGT1
*PKCd
*Coronin 1A
*CD27

Kate
On Oct 9, 2013, at 4:39 PM, Jason Raasch wrote:


Appreciate your thoughts/opinions:

In a patient (any age) who's basic immune evaluation for recurrent respiratory illness is unremarkable, how convinced are you that a persistently positive EBV VCA IgM (in the presence of EBV VCA IgG +/- EBNA) indicates chronic EBV infection or carrier status?  What if EBV PCR from peripheral blood is negative?

In other words, in your experience what is the SPECIFICITY of a persistently positive EBV VCA IgM ?  Are there some individuals who just never down-regulate EBV VCA IgM expression?

Thanks for your thoughts.

-Jason



Jason Raasch, MD

Midwest Immunology Clinic
15700 37th Ave N, Ste 110
Plymouth, MN 55446

TEL: (763) 577-0008
FAX: (763) 577-0192

---

The CIS-PIDD listserv is supported by:

[http://www.clinimmsoc.org/UserFiles/image/cis-pidd-list-logo_v1.jpg]
The science & practice of human immunology

P: +1.414.224.8095
E: info at clinimmsoc.org<mailto:info at clinimmsoc.org>

Not a member of CIS? Please visit www.clinimmsoc.org<https://cis.execinc.com/edibo/Signup> to join!

You are currently subscribed to cis-pidd as: sullivak at mail.med.upenn.edu<mailto:sullivak at mail.med.upenn.edu>.
To unsubscribe click here: http://lm.clinimmsoc.org/u?id=183824771.d123d252090ca5b0b32c510b919da279&n=T&l=cis-pidd&o=43947607

Kate Sullivan, MD PhD
Professor of Pediatrics
ARC 1216 Immunology CHOP
3615 Civic Center Blvd.
Philadelphia, PA 19104
(p) 215-590-1697
(f) 267-426-0363


---

The CIS-PIDD listserv is supported by:

[http://www.clinimmsoc.org/UserFiles/image/cis-pidd-list-logo_v1.jpg]
The science & practice of human immunology

P: +1.414.224.8095
E: info at clinimmsoc.org<mailto:info at clinimmsoc.org>

Not a member of CIS? Please visit www.clinimmsoc.org<https://cis.execinc.com/edibo/Signup> to join!

You are currently subscribed to cis-pidd as: jchurch at chla.usc.edu<mailto:jchurch at chla.usc.edu>.
To unsubscribe click here: http://lm.clinimmsoc.org/u?id=183824426.292477f2b5b77a2887c3a0060aad53a7&n=T&l=cis-pidd&o=43947660


---------------------------------------------------------------------
CONFIDENTIALITY NOTICE: This e-mail message, including any attachments, 
is for the sole use of the intended recipient(s) and may contain confidential
or legally privileged information. Any unauthorized review, use, disclosure
or distribution is prohibited. If you are not the intended recipient, please
contact the sender by reply e-mail and destroy all copies of this original message.  

---------------------------------------------------------------------


---
The CIS-PIDD listserv is supported by the Clinical Immunology Society
The science & practice of human immunology

P: +1.414.224.8095
E: info at clinimmsoc.org

Not a member of CIS? Please visit www.clinimmsoc.org to join!

You are currently subscribed to cis-pidd as: pagid at list.clinimmsoc.org.
To unsubscribe click here: http://lm.clinimmsoc.org/u?id=183939985.3ea13d40a15475ac00ebbd9cd8a37d6d&n=T&l=cis-pidd&o=43947676
or send a blank email to leave-43947676-183939985.3ea13d40a15475ac00ebbd9cd8a37d6d at lists.clinimmsoc.org
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://seven.pairlist.net/pipermail/pagid/attachments/20131009/595b0bc0/attachment-0001.html>