[CIS PIDD] [cis-pidd] 14yo with recurrent Staph aureus sepsis
Church, Joseph
JChurch at chla.usc.edu
Wed Jun 4 15:00:32 EDT 2014
I know of no clinical lab doing anti-cytokine autoantibody testing.
I have sent anti-IFNgamma to Sarah at NIH. Anne Puel in Paris does anti-IL17/IL22 and, I think still offers anti-IL6.
JC
From: Jason Raasch [mailto:jraasch at midwestimmunology.com]
Sent: Wednesday, June 04, 2014 11:53 AM
To: CIS-PIDD
Subject: Re: RE: [cis-pidd] 14yo with recurrent Staph aureus sepsis
Nima,
I think this is a good consideration but a practical question is where to have this done in the U.S. Sarah Browne discussed cytokine antibodies at CIS 2014 but I believe part of the talk was measuring these is largely on an investigational basis at the NIH.
Joe and others: are you aware of anywhere else to assess for cytokine Ab's?
-J
Jason Raasch, MD
Midwest Immunology Clinic
15700 37th Ave N, Ste 110
Plymouth, MN 55446
TEL: (763) 577-0008
FAX: (763) 577-0192
On 6/3/14 11:20 AM, Nima Parvaneh wrote:
Dear Joe,
Did you check the anti-IL6 autoantibodies. as the patient had a normal past medical history during the early years, he most probably have an acquired condition. Please see the following ref:
Recurrent staphylococcal cellulitis and subcutaneous abscesses in a child with autoantibodies against IL-6.<http://www.ncbi.nlm.nih.gov/pubmed/18097067> J Immunol. 2008 Jan 1;180(1):647-54
Yours,
nima.
On 2014-06-03 17:59, Church, Joseph wrote:
His skin is normal, no eczema, fungal infections, warts etc. IgE is pending; no eosinophilia. JC
From: Heimall, Jennifer [mailto:heimallj at email.chop.edu]
Sent: Monday, June 02, 2014 8:17 PM
To: CIS-PIDD
Subject: Re: [cis-pidd] 14yo with recurrent Staph aureus sepsis
Any other history of eczema, fungal infection or warts? Any elevation in ige or eosinophilia? I am thinking of perhaps a DOCk8- some were not too sick until their teens.
Jen
Sent from my iPhone
On Jun 2, 2014, at 7:56 PM, "Church, Joseph" <JChurch at chla.usc.edu<mailto:JChurch at chla.usc.edu>> wrote:
Colleagues:
I was asked to evaluate a previously very healthy 14yo boy who experienced the following:
* 2012 Cellulitis (likely Staph) after an insect bite
* 2013 Staph aureus, methicillin sensitive, septic shock after minor skin trauma and possible local infection
* 2014 Staph aureus, methicillin sensitive, sepsis.
He has a past history of a 4mm VSD, but echocardiography on two occasions failed to reveal a focus of infection.
Neutrophil counts were repeatedly normal.
Physical exam is normal except for a III/VI ejection murmur.
I have never read that CGD or LAD presents like this. I plan to suggest a closer look at his heart valves. Any other suggestions?
Joe Church
Children's Hospital Los Angeles
---------------------------------------------------------------------
CONFIDENTIALITY NOTICE: This e-mail message, including any attachments,
is for the sole use of the intended recipient(s) and may contain confidential
or legally privileged information. Any unauthorized review, use, disclosure
or distribution is prohibited. If you are not the intended recipient, please
contact the sender by reply e-mail and destroy all copies of this original message.
---------------------------------------------------------------------
---
The CIS-PIDD listserv is supported by:
[X]
The science & practice of human immunology
P: +1.414.224.8095
E: info at clinimmsoc.org<mailto:info at clinimmsoc.org>
Not a member of CIS? Please visit www.clinimmsoc.org<javascript:void(0);> to join!
You are currently subscribed to cis-pidd as: heimallj at email.chop.edu<mailto:heimallj at email.chop.edu>.
To unsubscribe click here: http://lm.clinimmsoc.org/u?id=183824501.906e93a1a559050da00131563850ac9e&n=T&l=cis-pidd&o=44964425
---
The CIS-PIDD listserv is supported by:
[X]
The science & practice of human immunology
P: +1.414.224.8095
E: info at clinimmsoc.org<mailto:info at clinimmsoc.org>
Not a member of CIS? Please visit www.clinimmsoc.org<javascript:void(0);> to join!
You are currently subscribed to cis-pidd as: jchurch at chla.usc.edu<mailto:jchurch at chla.usc.edu>.
To unsubscribe click here: http://lm.clinimmsoc.org/u?id=183824426.292477f2b5b77a2887c3a0060aad53a7&n=T&l=cis-pidd&o=44965265
---------------------------------------------------------------------
CONFIDENTIALITY NOTICE: This e-mail message, including any attachments,
is for the sole use of the intended recipient(s) and may contain confidential
or legally privileged information. Any unauthorized review, use, disclosure
or distribution is prohibited. If you are not the intended recipient, please
contact the sender by reply e-mail and destroy all copies of this original message.
---------------------------------------------------------------------
---
The CIS-PIDD listserv is supported by:
[X]
The science & practice of human immunology
P: +1.414.224.8095
E: info at clinimmsoc.org<mailto:info at clinimmsoc.org>
Not a member of CIS? Please visit www.clinimmsoc.org<javascript:void(0);> to join!
You are currently subscribed to cis-pidd as: nparvaneh at tums.ac.ir<mailto:nparvaneh at tums.ac.ir>.
To unsubscribe click here: http://lm.clinimmsoc.org/u?id=203293272.fbe7f035f71ca40b03d323eb16a8855f&n=T&l=cis-pidd&o=44966681
--
Nima Parvaneh, MD.
Assistant Professor
Department of Pediatrics
Division of Allergy and Clinical Immunology
Tehran University of Medical Sciences
62 Gharib St, 14194 Tehran, Iran
Tel: +98-21-66920982
Fax: +98-21-66923054
Email: nparvaneh at tums.ac.ir<mailto:nparvaneh at tums.ac.ir>
---
The CIS-PIDD listserv is supported by:
[http://www.clinimmsoc.org/UserFiles/image/cis-pidd-list-logo_v1.jpg]
The science & practice of human immunology
P: +1.414.224.8095
E: info at clinimmsoc.org<mailto:info at clinimmsoc.org>
Not a member of CIS? Please visit www.clinimmsoc.org<javascript:void(0);> to join!
You are currently subscribed to cis-pidd as: jraasch at midwestimmunology.com<mailto:jraasch at midwestimmunology.com>.
To unsubscribe click here: http://lm.clinimmsoc.org/u?id=183824721.ffecac98ebae3cc3c3ba17e837b8e976&n=T&l=cis-pidd&o=44967129
---
The CIS-PIDD listserv is supported by:
[http://www.clinimmsoc.org/UserFiles/image/cis-pidd-list-logo_v1.jpg]
The science & practice of human immunology
P: +1.414.224.8095
E: info at clinimmsoc.org<mailto:info at clinimmsoc.org>
Not a member of CIS? Please visit www.clinimmsoc.org<https://cis.execinc.com/edibo/Signup> to join!
You are currently subscribed to cis-pidd as: jchurch at chla.usc.edu<mailto:jchurch at chla.usc.edu>.
To unsubscribe click here: http://lm.clinimmsoc.org/u?id=183824426.292477f2b5b77a2887c3a0060aad53a7&n=T&l=cis-pidd&o=44972424
---------------------------------------------------------------------
CONFIDENTIALITY NOTICE: This e-mail message, including any attachments,
is for the sole use of the intended recipient(s) and may contain confidential
or legally privileged information. Any unauthorized review, use, disclosure
or distribution is prohibited. If you are not the intended recipient, please
contact the sender by reply e-mail and destroy all copies of this original message.
---------------------------------------------------------------------
---
The CIS-PIDD listserv is supported by the Clinical Immunology Society
The science & practice of human immunology
P: +1.414.224.8095
E: info at clinimmsoc.org
Not a member of CIS? Please visit www.clinimmsoc.org to join!
You are currently subscribed to cis-pidd as: pagid at list.clinimmsoc.org.
To unsubscribe click here: http://lm.clinimmsoc.org/u?id=183939985.3ea13d40a15475ac00ebbd9cd8a37d6d&n=T&l=cis-pidd&o=44972455
or send a blank email to leave-44972455-183939985.3ea13d40a15475ac00ebbd9cd8a37d6d at lists.clinimmsoc.org
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://seven.pairlist.net/pipermail/pagid/attachments/20140604/48053e4f/attachment-0001.html>
More information about the PAGID
mailing list