[CIS PIDD] [cis-pidd] 14yo with recurrent Staph aureus sepsis

Wed Jun 4 16:38:31 EDT 2014

Maybe Jean-Laurent Casanova at the Rockefeller do this test. did you ask
him? 

Nima. 

On 2014-06-04 23:30, Church, Joseph wrote: 

> I know of no clinical lab doing anti-cytokine autoantibody testing. 
> 
> I have sent anti-IFNgamma to Sarah at NIH. Anne Puel in Paris does anti-IL17/IL22 and, I think still offers anti-IL6. 
> 
> JC 
> 
> FROM: Jason Raasch [mailto:jraasch at midwestimmunology.com] 
> SENT: Wednesday, June 04, 2014 11:53 AM
> TO: CIS-PIDD
> SUBJECT: Re: RE: [cis-pidd] 14yo with recurrent Staph aureus sepsis 
> 
> Nima, 
> 
> I think this is a good consideration but a practical question is where to have this done in the U.S. Sarah Browne discussed cytokine antibodies at CIS 2014 but I believe part of the talk was measuring these is largely on an investigational basis at the NIH. 
> 
> Joe and others: are you aware of anywhere else to assess for cytokine Ab's? 
> 
> -J
> 
> Jason Raasch, MD
> 
> Midwest Immunology Clinic
> 15700 37th Ave N, Ste 110
> Plymouth, MN 55446
> 
> TEL: (763) 577-0008
> FAX: (763) 577-0192
> 
> On 6/3/14 11:20 AM, Nima Parvaneh wrote: 
> 
> Dear Joe, 
> 
> Did you check the anti-IL6 autoantibodies. as the patient had a normal past medical history during the early years, he most probably have an acquired condition. Please see the following ref: 
> 
> Recurrent STAPHYLOCOCCAL cellulitis and subcutaneous abscesses in a child with autoantibodies against IL-6. [1] J Immunol. 2008 Jan 1;180(1):647-54 
> 
> Yours, 
> 
> nima. 
> 
> On 2014-06-03 17:59, Church, Joseph wrote: 
> 
> His skin is normal, no eczema, fungal infections, warts etc. IgE is pending; no eosinophilia. JC 
> 
> FROM: Heimall, Jennifer [mailto:heimallj at email.chop.edu]
> SENT: Monday, June 02, 2014 8:17 PM
> TO: CIS-PIDD
> SUBJECT: Re: [cis-pidd] 14yo with recurrent Staph aureus sepsis 
> 
> Any other history of eczema, fungal infection or warts? Any elevation in ige or eosinophilia? I am thinking of perhaps a DOCk8- some were not too sick until their teens. 
> 
> Jen
> 
> Sent from my iPhone 
> 
> On Jun 2, 2014, at 7:56 PM, "Church, Joseph" <JChurch at chla.usc.edu> wrote: 
> 
> Colleagues: 
> 
> I was asked to evaluate a previously very healthy 14yo boy who experienced the following: 
> 
> · 2012 Cellulitis (likely Staph) after an insect bite 
> 
> · 2013 Staph aureus, methicillin sensitive, septic shock after minor skin trauma and possible local infection 
> 
> · 2014 Staph aureus, methicillin sensitive, sepsis. 
> 
> He has a past history of a 4mm VSD, but echocardiography on two occasions failed to reveal a focus of infection. 
> 
> Neutrophil counts were repeatedly normal. 
> 
> Physical exam is normal except for a III/VI ejection murmur. 
> 
> I have never read that CGD or LAD presents like this. I plan to suggest a closer look at his heart valves. Any other suggestions? 
> 
> Joe Church 
> 
> Children's Hospital Los Angeles 
> 
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-- 

Nima Parvaneh, MD.

Assistant Professor

Department of Pediatrics

Division of Allergy and Clinical Immunology

Tehran University of Medical Sciences

62 Gharib St, 14194 Tehran, Iran

Tel: +98-21-66920982

Fax: +98-21-66923054

Email: nparvaneh at tums.ac.ir

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-- 

Nima Parvaneh, MD.
Assistant Professor
Department of Pediatrics
Division of Allergy and Clinical Immunology
Tehran University of Medical Sciences
62 Gharib St, 14194 Tehran, Iran
Tel: +98-21-66920982
Fax: +98-21-66923054
Email: nparvaneh at tums.ac.ir

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