[CIS PIDD] [cis-pidd] Milder CVID phenotype with pregnancy

[Kirkpatrick, Charles]

I have done that with patients during the late stages of pregnancy.  My rationale was the same as yours.  Of course there are no controls, but the babies had no problems with infections as neonates.

Chuck Kirkpatrick, M.D.
Univ. of Colorado

From: Zachary D. Jacobs, MD [mailto:zjacobs.md at gmail.com]
Sent: Wednesday, June 04, 2014 2:02 PM
To: CIS-PIDD
Subject: [cis-pidd] Milder CVID phenotype with pregnancy

Dear Colleagues,

I am following a 34 year old woman with a milder CVID phenotype characterized by an IgG in the mid 400s, IgA in the 30s, normal IgM and a moderate specific antibody deficiency with pre/post Pneumovax testing.  Her pattern of infections has not been that bad at all and since her diagnosis about 18 months ago we have just been watching her and she has doing really well just with expectant/supportive therapy - no supplemental immunoglobulin.

She is now 21 weeks pregnant and still doing well. However, I was wondering if it might be beneficial to give her 1-2 doses of IVIG in the third trimester leading up to birth to optimize passive transfer of IgG to the baby, thinking that it might be better off for the infant to have a more "normal"  IgG at birth so the physiologic nadir won't hit rock bottom with him/her.

Any thoughts or experience with this scenario would be appreciated.

Thanks as always.

Zach

--
Zachary D. Jacobs, M.D.

The Center for Allergy & Immunology

Kansas City Physician Partners
Medical Plaza II
4330 Wornall, Suite 40
Kansas City, MO 64111

Ph: 816.531.0930
Fax: 816.753.2671

CONFIDENTIALITY NOTICE. This e-mail and attachments (if any) may contain information that is confidential, proprietary, privileged or otherwise prohibited by law from disclosure or re-disclosure. This information is intended solely for the individual(s) or entity(ies) to whom this e-mail or attachments are addressed. If you have received this e-mail in error, you are prohibited from using, copying, saving or disclosing this information to anyone else. Please destroy the message and any attachments immediately and notify the sender by return e-mail. Thank you.

P Please consider the environment before printing this message.


---

The CIS-PIDD listserv is supported by:

[cid:image001.jpg at 01CF80A9.0A7E9550]
The science & practice of human immunology

P: +1.414.224.8095
E: info at clinimmsoc.org

Not a member of CIS? Please visit www.clinimmsoc.org<https://cis.execinc.com/edibo/Signup> to join!

You are currently subscribed to cis-pidd as: charles.kirkpatrick at ucdenver.edu<mailto:charles.kirkpatrick at ucdenver.edu>.
To unsubscribe click here: http://lm.clinimmsoc.org/u?id=183824540.98e4b436b33e48e3ec338a2d996b2a64&n=T&l=cis-pidd&o=44972752

---
The CIS-PIDD listserv is supported by the Clinical Immunology Society
The science & practice of human immunology

P: +1.414.224.8095
E: info at clinimmsoc.org

Not a member of CIS? Please visit www.clinimmsoc.org to join!

You are currently subscribed to cis-pidd as: pagid at list.clinimmsoc.org.
To unsubscribe click here: http://lm.clinimmsoc.org/u?id=183939985.3ea13d40a15475ac00ebbd9cd8a37d6d&n=T&l=cis-pidd&o=44976481
or send a blank email to leave-44976481-183939985.3ea13d40a15475ac00ebbd9cd8a37d6d at lists.clinimmsoc.org
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://seven.pairlist.net/pipermail/pagid/attachments/20140605/093e909a/attachment-0001.html>
-------------- next part --------------
A non-text attachment was scrubbed...
Name: image001.jpg
Type: image/jpeg
Size: 620 bytes
Desc: image001.jpg
URL: <http://seven.pairlist.net/pipermail/pagid/attachments/20140605/093e909a/attachment-0001.jpg>