[CIS PIDD] [cis-pidd] Neutropenia and low interferon gamma production

[Wiens, Lynn A MD]

Initially, he had frequent episodes of cellulitis and one pneumonia. Did
culture MRSA with one of the skin lesions.  Cellulitis has greatly
improved with treatment. 

 

Lynn A. Wiens, MD

Cell: 918-550-1200

http://tulsaallergynews.com <http://tulsaallergynews.com> 

 

 

From: Kumar, Ashish [mailto:Ashish.Kumar at cchmc.org] 
Sent: Thursday, September 04, 2014 09:29
To: CIS-PIDD
Subject: RE:[cis-pidd] Neutropenia and low interferon gamma production

 

Has he had any serious pyogenic infections or was the neutropenia
discovered on CBC? Most children of this age will have benign autoimmune
neutropenia for which Neupogen is not really necessary. I am not sure
what to make of all the other results in the context of a healthy child.

 

Ashish Kumar, MD, PhD

Cancer and Blood Diseases Institute

Division of Bone Marrow Transplantation and Immune Deficiency

Cincinnati Children's Hospital Medical Center

http://www.cincinnatichildrens.org/bio/k/ashish-kumar/

http://www.cincinnatichildrens.org/research/divisions/b/bone-marrow/labs
/kumar/default/

 

From: Wiens, Lynn A MD [mailto:lawiens at saintfrancis.com] 
Sent: Thursday, September 04, 2014 10:01 AM
To: CIS-PIDD
Subject: [cis-pidd] Neutropenia and low interferon gamma production

 

I am taking care of a 2 yo male with idiopathic neutropenia doing well
on Neupogen.  As part of his work-up, I obtained T-cell function and PHA
did upregulate CD 69 but there was no interferon gamma production.  In
vitro proliferation to tetanus toxoid, viral mixture, candida was low.
Response to PWM; staph superantigen was normal.  

My question is what additional genetic testing is indicated in a boy
doing well with neupogen; no additional infections since starting.  

Lynn A. Wiens, MD

Warren Clinic

6160 South Yale Avenue  Tulsa, OK 74136

Specializing in the care of Allergy, Asthma, Sinus disease, and Chronic
Infections

http://tulsaallergynews.com <http://tulsaallergynews.com> 

Office: 918-495-2636

Cell: 918-550-1200

 

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