[CIS PIDD] [cis-pidd] Neutropenia and low interferon gamma production

[Cunningham-Rundles, Charlotte]

Was there a shipping control sent and was it ok?


Charlotte Cunningham-Rundles, MD, PhD

Departments of Medicine and Pediatrics

The David S Gottesman Professor

The Immunology Institute

Mount Sinai School of Medicine

1425 Madison Avenue

New York, NY 10029

Phone: 212 659 9268

Fax: 212 987 5593

Email: Charlotte.Cunningham-Rundles at mssm.edu


From: <Wiens>, Lynn A MD <lawiens at saintfrancis.com<mailto:lawiens at saintfrancis.com>>
Reply-To: "cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>" <cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>>
Date: Thursday, September 4, 2014 at 10:38 AM
To: "cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>" <cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>>
Subject: RE: [cis-pidd] Neutropenia and low interferon gamma production

Immunoglobulin levels are normal and the assay was performed at Viracor-IBT using their T-cell FX complete panel.

Lynn A. Wiens, MD
Cell: 918-550-1200
http://tulsaallergynews.com<https://urldefense.proofpoint.com/v1/url?u=http://tulsaallergynews.com&k=PFsgZv%2B4TEaU9fTpAWpLNw%3D%3D%0A&r=95bjMIk6%2FpQi8M8NxygcLXhTmLuSpeqipW0xWWEJ2aQ9xW4xyHPuIJ70yXVpxdNM%0A&m=2YepyoKMiAkKVHwZ8TqVBszI34BhgwWxnj25sgAFXVA%3D%0A&s=0bd3ea7522799146ec25ad1c33216d0e79d526149eba63d2405d16279e24ceec>
[cid:image002.png at 01CFC823.F61B5270]

From: Church, Joseph [mailto:JChurch at chla.usc.edu]
Sent: Thursday, September 04, 2014 09:11
To: CIS-PIDD
Subject: RE:[cis-pidd] Neutropenia and low interferon gamma production

What assay was done for INF-g production?

Were immunoglobulin levels normal?

Joe Church
Children’s Hospital Los Angeles

From: Wiens, Lynn A MD [mailto:lawiens at saintfrancis.com]
Sent: Thursday, September 04, 2014 7:01 AM
To: CIS-PIDD
Subject: [cis-pidd] Neutropenia and low interferon gamma production


I am taking care of a 2 yo male with idiopathic neutropenia doing well on Neupogen. As part of his work-up, I obtained T-cell function and PHA did upregulate CD 69 but there was no interferon gamma production.  In vitroproliferation to tetanus toxoid, viral mixture, candida waslow.  Response to PWM; staph superantigen was normal.

My question is what additional genetic testing is indicated in a boy doing well with neupogen; no additional infections since starting.

Lynn A. Wiens, MD

Warren Clinic

6160 South Yale Avenue  Tulsa, OK 74136

Specializing in the care of Allergy, Asthma, Sinus disease, and Chronic Infections

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Office: 918-495-2636

Cell: 918-550-1200

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