[CIS PIDD] [cis-pidd] Neutropenia and low interferon gamma production

Thu Sep 4 17:25:04 EDT 2014

the CD4  CD8 NK CD19 was normal?
We have a similar case neutropenia but AMO was normal, no maduration
arrest. He recived FSC GM filgastrim with low answer. but present
lymphopenia

  *HEMOGRAMA*

19/07/14

21/07/14

29/07/14

3/08/14

4/08/14

*LEUCOS*

1530/mm3

1120/mm3

1100/mm3

9900/nn3

3610/mm3

*ABAST*

0%

0%

1%

4%

0%

*SEGM*

49%

7%

22%

88%

76%

*LINFOCITOS*

48% 720

87% 957

75% 825

8% 792

16% 576

*MONOCITOS*

3%

5%

2%

--

6%

*HTO*

32%

33%

30%

30%

33%

*HB*

9.9gr/dl

10.6gr/dl

9.2gr/dl

9.6gr/dl

10.3gr/dl

*PLAQUETAS*

484000/mm3

514000/mm3

371000/mm3

450000/mm3

401000/mm3

*RECUENTO ABSOLUTO*

*VALORES REFERENCIALES*

*LINFOCITOS TCD3+*

509

900 A 5400cel/ul

*LINFOCITOS T CD3   CD4*

85

500 a 2400cel/ul

*LINFOCITOS T CD3    CD8*

274

300 a 1600 cel/ul

*RELACION CD4/CD8*

0.31

0.9 a 2.9

*% CD4+ DE LINFOCITOS T*

17

*% CD8+ DE LINFOCITOS T*

54

*LINFOCITOS B  CD19+*

284

200 a 2100 cel/ul

*NK CD56/16*

114

100 a 1000cel/ul

*LINFOCITOS TOTALES*

941

*LEUCOCITOS TOTALES (CD45+)*

1583

*Globulinas*

2.8gr/dl

*Ig A*

114mg/dl

*Ig G*

1068mg/dl

*Ig M*

82mg/dl

2014-09-04 9:00 GMT-05:00 Wiens, Lynn A MD <lawiens at saintfrancis.com>:

>  I am taking care of a 2 yo male with idiopathic neutropenia doing well
> on Neupogen.  As part of his work-up, I obtained T-cell function and PHA
> did upregulate CD 69 but there was no interferon gamma production.  In vitro
> proliferation to tetanus toxoid, viral mixture, candida was low.
> Response to PWM; staph superantigen was normal.
>
> My question is what additional genetic testing is indicated in a boy doing
> well with neupogen; no additional infections since starting.
>
> Lynn A. Wiens, MD
>
> Warren Clinic
>
> 6160 South Yale Avenue  Tulsa, OK 74136
>
> Specializing in the care of Allergy, Asthma, Sinus disease, and Chronic
> Infections
>
> *http://tulsaallergynews.com* <http://tulsaallergynews.com>
>
> Office: 918-495-2636
>
> Cell: 918-550-1200
>
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>
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-- 
*Atte *
Wilmer Córdova
*Inmunología Alergología*
*Instituto Nacional de Salud del Niño - Perú*
http://www.isn.gob.pe
wcordova at insn.gob.pe
facebook.com/wilmer.cordova.71
twitter: @wilmer_cordova

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