[CIS PIDD] [cis-pidd] therapeutic advise for severe Respiratory papillomatosis (RRP)

[Laham, Federico R.]

I am following a 5yo boy with Recalcitrant papillomatosis. He had some response to intralesional  cidofovir, but did not modified the disease course. gardasil x 3 doses (at the age of 2.5 years) did not objectively help. Immune studies normal except for decreased NK cytotoxicity that we are repeating.

Celebrex seems to be making a great difference, and now he goes to the OR every 7-8 weeks (used to go every 2-3 weeks due to severe stridor).

Parents have declined interferon. Cidofovir weekly x 4 weeks, then biweekly x 3 caused no improvement.

Federico Laham, MD
Pediatric Infectious Diseases
Arnold Palmer Hospital for Children
Orlando, FL

On Sep 26, 2014, at 2:05 PM, Elie Haddad <elie.haddad at umontreal.ca<mailto:elie.haddad at umontreal.ca>> wrote:

Dear colleagues,
We have a 13 yo patient with severe respiratory papillomatosis.
Her lesions are progressing in the larynx and although a new surgery is scheduled, the ENT specialist is very worried and asked us for help.
I know that some years ago, someone posted the feasibility of IFNa in aerosol for these patients, but I cannot find the post.
Does anyone know how to do this (doses, frequency, solution) ?
Do you think it is a good idea ?
Do you think we should give systemic IFNa also (or only) ?
Any anti-viral drug that could help ?
Thanks
Elie


Elie Haddad, MD, PhD,
Professor of Pediatrics, University of Montreal,
Head, Pediatric Immunology and Rheumatology Division,
CHU Sainte-Justine, 3175 Cote Sainte-Catherine
Montreal, QC, H3T 1C5, Canada
Ph: 1 514 345 4713
fax: 1 514 345 4897
e-mail: elie.haddad at umontreal.ca<mailto:elie.haddad at umontreal.ca>






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