[CIS PIDD] [cis-pidd] HSCT experience in prolidase deficiency?

[Carsten Speckmann]

Dear all,

some of you may have received this request already via the IEWP mailing list. 
So far the feedback was limited, but maybe some of you have experience with this rare disorder?

We are seeing a 4y/o boy with a very severe course of prolidase deficiency - a rare connective tissue disorder. 
 
I wonder about the HSCT experience for this disease within the CIS community. 
 
In literature there is one reported HSCT case (Caselli et al) with promising initial results, but the patient deceased around d+100 from infectious complications.
I have recently heard about one successfully treated pt (still awaiting more details).
 
Gene therapy or enzyme replacement therapy has been discussed in literature, but (to my knowledge) is not available at present. 
I wonder whether  HSCT might be a considerable option in severely affected  patients. Any center experience with this?
 
Thanks a lot, best wishes Carsten Speckmann

-- 
Dr. Carsten Speckmann
Pediatrician
Group Leader: Benign lymphoproliferative disorders
Pediatric Hematology and Oncology
and Center for Chronic Immunodeficiency
University of Freiburg
Germany
phone: +49 (0)761 270 43010
fax: +49 (0)761 270 45990
www.uniklinik-freiburg.de/cci/studien/alps.html



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