[CIS PIDD] [cis-pidd] conditioning for RMRP SCID

[Joanne Smart]

Dr Joanne Smart
BSc. MBBS. PhD. FRACP

Clinical Allergist & Immunologist
Department of Allergy and Immunology
Royal Children's Hospital
Flemington Rd
Parkville, VIC 3052
AUSTRALIA

Tel: +61 3 9345 5522
Fax: +61 3 9345 4848
email: joanne.smart at rch.org.au<mailto:joanne.smart at rch.org.au>
________________________________
From: John Ziegler <j.ziegler at unsw.edu.au>
Sent: Thursday, 6 November 2014 4:15 PM
To: CIS-PIDD
Subject: RE:[cis-pidd] conditioning for RMRP SCID

That was VOD attributed to busulphan. Doesn't suggest unusual sensitivity. VOD was not reported in http://www.ncbi.nlm.nih.gov/pubmed/?term=20375313


From: Christine M. Seroogy, MD [mailto:cmseroogy at pediatrics.wisc.edu]
Sent: Thursday, 6 November 2014 3:09 PM
To: CIS-PIDD
Subject: [cis-pidd] conditioning for RMRP SCID



Dear Colleagues,

We have a new RMRP SCID case  picked up by NBS SCID screening.  We are moving to HSCT with a well-matched cord.  Are any of you aware of increased sensitivity to conditioning in these patients?  The literature does not suggest this, but the recent JAMA publication on NBS SCID screening(
PMID:
25138334)
reported  1 of the 2 RMRP SCID infants had complications from conditioning. May simply be age- or conditioning-regimen-related and not the genetic defect.

Thank you,

Chris


Christine M. Seroogy MD,  FAAAAI
Associate Professor
University of Wisconsin School of Medicine and Public Health
Department of Pediatrics
Division of Allergy, Immunology & Rheumatology
1111 Highland Avenue
4139 WIMR
Madison, WI  53705-2275
phone: 608-263-2652
fax: 608-263-4226






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