[CIS PIDD] [cis-pidd] VS: is there any Factor H replacement therapy?

[Martelius Timi]

Liver transplant?

Timi Martelius MD
Dept of Infectious Diseases
Helsinki University Hospital

Lähettäjä: Lourdes Tricas Aizpun [mailto:lourdes.tricas at sespa.es]
Lähetetty: 28. maaliskuuta 2015 12:33
Vastaanottaja: CIS-PIDD
Aihe: [MARKETING][cis-pidd] Fwd: is there any Factor H replacement therapy?



________________________________
De: "Lourdes Tricas Aizpun" <lourdes.tricas at sespa.es<mailto:lourdes.tricas at sespa.es>>
Para: cis-pidd at lysis.dundee.net<mailto:cis-pidd at lysis.dundee.net>
Enviados: Viernes, 27 de Marzo 2015 17:11:55
Asunto: is there any Factor H replacement therapy?

Dear colleagues,
 Clinical case:
 Family History:
 Family Factor H of Complement system deficiency. 2 dead sisters. They had glomerulonephritis and severe infections.

Patient History:
 Woman  50 years old, factor H deficiency, HCV positive.
1982.- meningococcal sepsis & membrano-proliferative glomerulonephritis.
1996.- kidney transplant.
2000.- gastroenteritis due to salmonella enteriditis.
2005.- graft loss due to recurrence of glomerulonephritis.
2009.- Second kidney transplant and consequently immunosuppressive treatment.
At he present time several and severe  urinary infections.

Questions:
 Aside from to be immunized with polyvalent meningococcal vaccine we wonder if there is a Factor H replacement therapy with synthesized Factor H or with healthy plasma in the case of severe life-threatening sepsis.

Thank you for your help, comments and teaching.
 Lourdes Tricas, MD PhD. Clinical Laboratory Immunologist.
Hospital Universitario Central de Asturias, Oviedo, Spain
lourdes.tricas at sespa.es<mailto:lourdes.tricas at sespa.es>





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