[CIS PIDD] [cis-pidd] Fwd: is there any Factor H replacement therapy?

[Lourdes Tricas Aizpun]

----- Mensaje reenviado -----

De: "Lourdes Tricas Aizpun" <lourdes.tricas at sespa.es> 
Para: cis-pidd at lysis.dundee.net 
Enviados: Viernes, 27 de Marzo 2015 17:11:55 
Asunto: is there any Factor H replacement therapy? 

Dear colleagues, 
 Clinical case: 
 Family History: 
 Family Factor H of Complement system deficiency. 2 dead sisters. They had glomerulonephritis and severe infections. 
  
Patient History: 
 Woman  50 years old, factor H deficiency, HCV positive. 
1982.- meningococcal sepsis & membrano-proliferative glomerulonephritis. 
1996.- kidney transplant. 
2000.- gastroenteritis due to salmonella enteriditis. 
2005.- graft loss due to recurrence of glomerulonephritis. 
2009.- Second kidney transplant and consequently immunosuppressive treatment. 
At he present time several and severe  urinary infections. 
  
Questions: 
 Aside from to be immunized with polyvalent meningococcal vaccine we wonder if there is a Factor H replacement therapy with synthesized Factor H or with healthy plasma in the case of severe life-threatening sepsis. 
  
Thank you for your help, comments and teaching. 
 Lourdes Tricas, MD PhD. Clinical Laboratory Immunologist. 
Hospital Universitario Central de Asturias, Oviedo, Spain 
lourdes.tricas at sespa.es 
  
  
  


---
You are currently subscribed to cis-pidd as: pagid at list.clinimmsoc.org.
To unsubscribe click here: http://cts.dundee.net/u?id=96396833.5a9591ccd1e327fe6bc4d1543298c482&n=T&l=cis-pidd&o=2704743
or send a blank email to leave-2704743-96396833.5a9591ccd1e327fe6bc4d1543298c482 at lyris.dundee.net
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <https://pairlist7.pair.net/pipermail/pagid/attachments/20150328/4d6e26bd/attachment-0001.html>