[CIS PIDD] [cis-pidd] IVIG/ScIg for Complement deficiency?

[Verbsky, James]

We have a couple of C2 patients.  We never use IVIG.  We use prophylaxis and yearly immunizations.



I know John Atkinson (Wash U) gives these pts Abx to take in case of a fever rather than daily prophylaxis, which we have also done.  We see no reason for IVIG



Best



James Verbsky MD/PhD
Associate Professor of Pediatrics and Microbiology and Molecular Genetics
Medical College of Wisconsin
Milwaukee, WI  53226

________________________________
From: Church, Joseph [JChurch at chla.usc.edu]
Sent: Tuesday, April 14, 2015 9:50 AM
To: CIS-PIDD
Subject: RE: [cis-pidd] IVIG/ScIg for Complement deficiency?

This makes no sense to me.  The patients’ problem is not the inability to make antibodies, it is the inability to use complement that is activated by the classical pathway (or lectin pathway) regardless of the source of antibodies.

Joe Church
Children’s Hospital Los Angeles

From: Jason Raasch [mailto:jraasch at midwestimmunology.com]
Sent: Monday, April 13, 2015 1:31 PM
To: CIS-PIDD
Subject: [cis-pidd] IVIG/ScIg for Complement deficiency?

Hello everyone.

I have heard of some practitioners in our region using IVIG as sole management for isolated C2 deficiency in infants/children (i.e. instead of prophylactic antibiotics, immunizations for encapsulated organisms, etc.).  The feeling is long-term use of prophylactic antibiotics in these cases is irresponsible.

I will be honest and admit I have not heard of this before or found much in the literature.  What am I missing here?

I would appreciate any comments.

Regards,

Jason


Jason Raasch, MD

Midwest Immunology Clinic
15700 37th Ave N, Ste 110
Plymouth, MN 55446

TEL: (763) 577-0008
FAX: (763) 577-0192







---

You are currently subscribed to cis-pidd as: jchurch at chla.usc.edu<mailto:jchurch at chla.usc.edu>.

To unsubscribe click here: http://cts.dundee.net/u?id=96396658.df9245d5219d19fc82ac9f3bbf52c836&n=T&l=cis-pidd&o=2754516

(It may be necessary to cut and paste the above URL if the line is broken)

or send a blank email to leave-2754516-96396658.df9245d5219d19fc82ac9f3bbf52c836 at lyris.dundee.net<mailto:leave-2754516-96396658.df9245d5219d19fc82ac9f3bbf52c836 at lyris.dundee.net>

---------------------------------------------------------------------
CONFIDENTIALITY NOTICE: This e-mail message, including any attachments,
is for the sole use of the intended recipient(s) and may contain confidential
or legally privileged information. Any unauthorized review, use, disclosure
or distribution is prohibited. If you are not the intended recipient, please
contact the sender by reply e-mail and destroy all copies of this original message.

---------------------------------------------------------------------

---

You are currently subscribed to cis-pidd as: jverbsky at mcw.edu<mailto:jverbsky at mcw.edu>.

To unsubscribe click here: http://cts.dundee.net/u?id=96396710.777d26b6da96d84a8b0d5e2d208337f2&n=T&l=cis-pidd&o=2756700

(It may be necessary to cut and paste the above URL if the line is broken)

or send a blank email to leave-2756700-96396710.777d26b6da96d84a8b0d5e2d208337f2 at lyris.dundee.net<mailto:leave-2756700-96396710.777d26b6da96d84a8b0d5e2d208337f2 at lyris.dundee.net>

---
You are currently subscribed to cis-pidd as: pagid at list.clinimmsoc.org.
To unsubscribe click here: http://cts.dundee.net/u?id=96396833.5a9591ccd1e327fe6bc4d1543298c482&n=T&l=cis-pidd&o=2757364
or send a blank email to leave-2757364-96396833.5a9591ccd1e327fe6bc4d1543298c482 at lyris.dundee.net