[CIS PIDD] [cis-pidd] recurrent Enterovirus meningitis

[Mikko Seppänen]

Dear Jennifer, 

two already by age 10 sounds to me also more than a coincidence. And no PAD...

I would ask Shen-Ying Zhang and Jean-Laurent Casanova, since enteroviridae belong to viruses that may benefit from TLR3 pathway deficiency, at least experimentally:

Curr Opin Immunol. 2013 Feb;25(1):19-33. doi: 10.1016/j.coi.2012.11.001. Epub 2013 Jan 3.
TLR3 immunity to infection in mice and humans.
Zhang SY1, Herman M, Ciancanelli MJ, Pérez de Diego R, Sancho-Shimizu V, Abel L, Casanova JL.

ATB, 

Mikko Seppänen MD
Finland

Leiding, Jennifer <jleiding at health.usf.edu> kirjoitti 22.4.2015 kello 18.50:

Hi all:

We are following an 11yo little girl who has had enterovirus meningitis twice with symptoms of headache, photophobia, nausea and emesis. The first episode was at age 9 and once last year. She also had 2 episodes of similar symptoms at age 3 and 6 but a lumbar puncture was never performed. She is growing well and is developmentally normal. Other infections have included pneumonia that was CXR documented 2 times treated with oral antibiotics and several episodes of otitis media. Her immune evaluation has included normal immunoglobulins, normal vaccine responses to diptheria, tetanus, and pneumococcus, and normal CH50, NK cell functional analysis, and lymphocyte subset analysis. T cell proliferative studies normal other than low response to Candida. 

MRI of the spine was performed in the last year due to low back pain and was normal. 


Any ideas about further evaluation?

Thanks,
Jennifer Leiding

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