[CIS PIDD] [cis-pidd] Enterovirus infection in WAS

[CIS-PIDD]

We know from the experience with Echovirus years ago that in XLA patients
you can even make the PCR negative with high dose IgG ( J. Inf. Dis.
161:787-791 )   but the virus is not eradicated. In the patient published
here, when the IgG level fell after years of no symptoms and negative Echo
11 PCR, he became symptomatic and Echo 11 positive again. I suggest high
dose IgG until the PCR is negative and continue at that dose until he is
reconstituted.

Richard Wasserman
Dallas

On Thu, Sep 17, 2015 at 12:41 AM, CIS-PIDD <cis-pidd at lists.clinimmsoc.org>
wrote:

> Dear Colleagues,
>
> I have a young man with WAS that developed fever, vomiting, and diarrhea.
> His symptoms quickly subsided.  I ended up detecting enterovirus by PCR.
> He is being considered for a matched sib transplant which will include
> serotherapy.   His serum PCR is still positive (qualitative).  I was
> wondering how other individuals have managed peri-transplant enterovirus
> infections with respect to the timing of transplant.  My inclination was to
> wait until he is negative.
>
> Sincerely,
>
> Dave Buchbinder, MD
> Division of Hematology
> CHOC Children's Hospital
>
> CHOCLX-MGSM made the following annotations
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> Wed Sep 16 2015 22:41:57
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-- 
Richard L. Wasserman, MD, PhD
Allergy Partners of North Texas
7777 Forest Lane, Suite B-332
Dallas, Texas 75230
Office (972) 566-7788
Fax (972) 566-8837
Cell (214) 697-7211

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