[CIS PIDD] [cis-pidd] Abatacept usage in LRBA

[CIS-PIDD]

The abatacept is catabolized similarly to IgG. Because IgG catabolism is
concentration dependent, it would be better to give the abatacept before
the IgG. Probably 1-2 days prior is enough. Alternatively, if you gave the
IgG subcut, there would be no elevated IgG and you could give the abatacept
any time.
Richard Wasserman
Dallas

On Thu, Mar 17, 2016 at 7:18 AM, CIS-PIDD <cis-pidd at lists.clinimmsoc.org>
wrote:

> Dear Luis,
> no adverse effects seen in one girl with 3-weekly IVIG (high-dose needed,
> 0.8g/kg) and 4-weekly abatacept (10-20mg/kg). We try to avoid giving the
> two infusions within the same calendar week.
> best, Markus
>
>
> Markus G. Seidel, M.D.
> Professor of Translational Pediatric Hematology and Immunology | Div. of
> Pediatric Hematology-Oncology | Dept. of Pediatric and Adolescent Medicine
> | Medical University Graz | Auenbruggerpl. 34/2 | A-8036 Graz | Austria |
> T. 0043 316 385 80215| F. 0043 316 385 13717 | Secr. 0043 316 385 13485 |
> Head of the Research Unit for Pediatric Hematology and Immunology |
> Coordinator of the Working Group for Pediatric Immunology of the Austrian
> Society of Pediatrics and Adolescent Medicine
>
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> Am 15.03.2016 um 21:11 schrieb CIS-PIDD <cis-pidd at lists.clinimmsoc.org>:
>
> Dear colleagues,
>
> We have recently diagnosed two LRBA patients with ongoing autoimmunity and
> lung disease, under IVIG and SQ each. My question is if you have
> experienced infusion adverse effects while subsequent IVIG+abatacept
> infusion. In your experience, is there any reason to use one specific route
> for abatacept in LRBA?
> Thanks in advance for your inputs,
>
>
> *Luis I. Gonzalez-Granado. MD.* Immunodeficiencies Unit.  Hospital 12 de
> octubre. Research Institute Hospital 12 octubre (i+12)
> Av. Cordoba S/N. 28041. Madrid. Spain
> Tel. *0034**606732959 / * 0034913908569  /  Fax 0034913908772
> <0034934893039>
>
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-- 
Richard L. Wasserman, MD, PhD
Allergy Partners of North Texas
7777 Forest Lane, Suite B-332
Dallas, Texas 75230
Office (972) 566-7788
Fax (972) 566-8837
Cell (214) 697-7211

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