[CIS PIDD] [cis-pidd] FW: Immunology question

[CIS-PIDD]

Colleagues:

A patient with tuberous sclerosis has been on immunosuppressant everolimus for quite some time to treat his subependymal giant cell astrocytoma.  This is a benign brain tumor that is responsive to everolimus.

The patient's mom would like to take him off of everolimus to give him the MMR and varicella vaccines.   His neurologist says it's OK to take him off for "a time."

My questions:

*         How long will the immunosuppressive effect of evrolimus last, i.e. when could he receive the live virus vaccines?

*         How long after the vaccines should they wait for immune responses to "take" before restarting the everolimus?

Thank you.

Joe Church
Children's Hospital Los Angeles





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