[CIS PIDD] [cis-pidd] Transplant for Hyper-IgM Syndrome

[CIS-PIDD]

Colleagues,
I care for a 7 year old with classic Hyper-IgM Syndrome (single base pain
substitution g.3715C>A in exon 2 [Genbank EF064753] of CD40L) who has
virtually never been sick. He was diagnosed early because of an affected
uncle and has been treated with IGSC and TMP-SMX prophylaxis.

He has a younger female sib who has not yet been tested. Neither have been
tissue typed.

When should this child be transplanted? Would the answer depend on the sib
matching? If the sib is not a match, what is the current feeling on cord
blood, MUD or haplo?

Thanks,
Richard

-- 
Richard L. Wasserman, MD, PhD
Allergy Partners of North Texas
7777 Forest Lane, Suite B-332
Dallas, Texas 75230
Office (972) 566-7788
Fax (972) 566-8837
Cell (214) 697-7211

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