[CIS PIDD] [cis-pidd] Rituximab s.c for GLILD therapy

[CIS-PIDD]

Dear colleagues, 

I intend to treat an adult CVID patient with GLILD with the
rituximab/Azathioprin regimen suggested by John M. Routes with four weekly
infusions of 375 mg/M2 i.v. that are then repeated every 4-6 month. As the
patient worries about the time off work it would be more convenient for her
to get Rituximab s.c. as the 1400 mg fix-dose given within a couple of
minutes instead of the infusions that take several hours.
Has anybody used the sc. version of Rituximab for GLILD/CVID and could
suggest a regimen that might in effect be similar to John Routes's iv.
regimen? Weekly injection of Rituximab 1400 mg do not seem to be in use for
Lymphoma and just giving replacing the weekly iv. doses by the sc. Dose
might be too much?

Thanks for advice!

Prof. Dr. Simon Rothenfusser
Immundefekt-Ambulanz für Erwachsene („AIDA“)
Medizinische Klinik IV
Klinikum der Ludwigs-Maximilian Universität
Pettenkoferstraße 8a, 80336 München

Tel. *49-89-4400-53568
Fax: 089/4400-53719
E-mail: Simon.rothenfusser at med.uni-muenchen.de

www.klinikum.uni-muenchen.de/Medizinische-Poliklinik-Innenstadt/de/rheumaein
heit/rheuma-ambulanz/



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