[CIS PIDD] [cis-pidd] B-cell subsets

CIS-PIDD cis-pidd at lists.clinimmsoc.org
Wed Feb 1 20:18:34 EST 2017


They are “low risk” CVIDs with infections only; no lymphoproliferative disorders, no GI symptoms, no autoimmune issues (?yet).  JC

From: CIS-PIDD [mailto:cis-pidd at lists.clinimmsoc.org]
Sent: Wednesday, February 01, 2017 5:16 PM
To: CIS-PIDD
Subject: RE: [cis-pidd] B-cell subsets


Hi Joe,

Do your patients have only infections or also other non-infectious manifestations of CVID?

Best,
Milica Mitrevski

Il 02.02.2017 01:07 CIS-PIDD ha scritto:
Yes, very normal numbers. JC

From: CIS-PIDD [mailto:cis-pidd at lists.clinimmsoc.org]
Sent: Wednesday, February 01, 2017 3:51 PM
To: CIS-PIDD
Subject: Re: [cis-pidd] B-cell subsets

Hi Joe,
Do the patients have normal numbers of B cells?
Best,
Jordan

From: CIS-PIDD <cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>>
Reply-To: CIS-PIDD <cis-pidd at lyris.dundee.net<mailto:cis-pidd at lyris.dundee.net>>
Date: Wednesday, February 1, 2017 at 2:34 PM
To: CIS-PIDD <cis-pidd at lyris.dundee.net<mailto:cis-pidd at lyris.dundee.net>>
Subject: [cis-pidd] B-cell subsets

Colleagues:

Several of my CVID patients have displayed phenotypes similar to the following:

•         CD19+ IgD+ CD27- (naïve)                        20%

•         CD19+ IgD+ CD27+ (memory)                  48%

•         CD19+ IgD- CD27+ (switched memory    31%

Are there specific “CVID” genotypes that are likely to present with this pattern?

Joe Church
Children’s Hospital Los Angeles

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Milica Mitrevski, MD, PhD Clinical Immunology and Allergy Specialist Sapienza University of Rome Department of Clinical Medicine Viale dell'Università 37, 00185 Rome, Italy tel: +39 06 49972036 +39 349 5622376 mail: mitmilica at tiscali.it<mailto:mitmilica at tiscali.it>

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