[CIS PIDD] [cis-pidd] ADA2 deficiency - Infliximab dosage

[CIS-PIDD]

Nope. 

Sent from my iPhone

> On 17 May 2017, at 05:15, CIS-PIDD <cis-pidd at lists.clinimmsoc.org> wrote:
> 
> Do you guys add methotrexate to prevent auto-antibody formation?
> (Fabian: our patients like adalimumab…)
> Best, Bodo
> ****************************************
> Univ.-Prof. Dr. med. B. Grimbacher
>  
> Scientific-Director
> CCI-Center for Chronic Immunodeficiency
> UNIVERSITÄTSKLINIKUM FREIBURG
> Tel.: 0761 270-77731  Fax: -77744
> Breisacherstraße 115, 79106 Freiburg
> bodo.grimbacher at uniklinik-freiburg.de 
> www.uniklinik-freiburg.de/cci
> 
> Von: <cis-pidd at lyris.dundee.net> on behalf of CIS-PIDD <cis-pidd at lists.clinimmsoc.org>
> Antworten an: CIS-PIDD <cis-pidd at lyris.dundee.net>
> Datum: Tuesday 16 May 2017 17:11
> An: CIS-PIDD <cis-pidd at lyris.dundee.net>
> Betreff: Re: [cis-pidd] ADA2 deficiency - Infliximab dosage
> 
> That is the standard IBD load.  I suggest you do proactive therapeutic drug monitoring after the load is complete to adjust the dosing.  Check level no sooner than 4 weeks after the third dose.  Ideally a true trough is helpful so 6 weeks after third dose  would be best. Infliximab is more antigenic (up to 25 percent can develop anti drug antibodies) than other anti TNFs so  I typically premedicate with Tylenol, Benadryl, and IV hydrocortisone.  
> 
> Infliximab level testing is available from labcorp, ARUP, Prometheus, Mayo lab, and Miraca for those of us in the US.  
> 
> Levels can be impacted by extends of disease, albumin, and degree of inflammation. 
> 
> Best,
> 
> SG
> 
> Sarah C. Glover, DO, AGAF
> Director, Inflammatory Bowel and Celiac Disease Program
> Associate Professor of Medicine
> University of Florida
> PO Box 103643 
> Gainesville, FL 32610 
> http://gastroliver.medicine.ufl.edu/ibd/
> Phone (UF Health patient access center): 352-273-9400 
> Phone (IBD research): 352-265-8971
> Phone (Cell): 312-933-8039
> Fax 352-265-8979​
> 
> 
> Sent from my iPhone
> 
> On May 16, 2017, at 11:00 AM, CIS-PIDD <cis-pidd at lists.clinimmsoc.org> wrote:
> 
>> Dear all,
>>  
>> I am planning to treat an ADA2 deficient patient with Infliximab and would like to know the dosage and the dosing intervall already used sucessfully.
>> Is it 5mg/kg at week 0, 2, 6 and thereafter every 8 weeks?
>>  
>> Thank you and best regards,
>>  
>> Fabian
>>  
>>  
>> Fabian Hauck, MD, PhD
>>  
>> Head Immunodeficiency Unit and Immunological Diagnostics Laboratoy
>> Pediatrics / Pediatric Hematology and Oncology / Immunology (DGfI)
>>  
>> Dr. von Hauner Children’s Hospital
>> Klinikum der Universität München 
>> Lindwurmstr. 4, 80337 München
>> Germany
>>  
>> Tel.: +49 89 4400-53931
>> Fax: +49 89 4400-53964
>> E-Mail: fabian.hauck at med.uni-muenchen.de
>>  
>>  
>> www.klinikum.uni-muenchen.de
>>  
>> <image001.png>
>>  
>> Das Klinikum der Universität München ist eine Anstalt des öffentlichen Rechts (AöR)
>> The Klinikum der Universität München is an Institution under Public Law
>>  
>>  
>>  
>> 
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