[CIS PIDD] [cis-pidd] ADA2 deficiency - Infliximab dosage

Wed May 17 10:21:02 EDT 2017

Another advantage of infliximab is the ability to use much higher doses for severe inflammatory conditions – see attached.

From: cis-pidd at lyris.dundee.net [mailto:cis-pidd at lyris.dundee.net] On Behalf Of CIS-PIDD
Sent: Tuesday, May 16, 2017 7:59 PM
To: CIS-PIDD <cis-pidd at lyris.dundee.net>
Subject: Re: [cis-pidd] ADA2 deficiency - Infliximab dosage

If there is a significant G.I. inflammatory component, etanercept will not work. It failed in IBD clinical trials.
Sarah C. Glover, DO, AGAF
Director, Inflammatory Bowel and Celiac Disease Program
Associate Professor of Medicine
University of Florida
PO Box 103643 <x-apple-data-detectors://1>
Gainesville, FL 32610<x-apple-data-detectors://1>
http://gastroliver.medicine.ufl.edu/ibd/
Phone (UF Health patient access center): 352-273-9400<tel:352-273-9400>
Phone (IBD research): 352-265-8971<tel:352-265-8971>
Phone (Cell): 312-933-8039<tel:312-933-8039>
Fax 352-265-8979<tel:352-265-8979>

Sent from my iPhone

On May 16, 2017, at 2:15 PM, CIS-PIDD <cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>> wrote:
Dear Fabian,

Why would you use infliximab as opposed to etanercept?

Isabelle Meyts, UZ Leuven

Op 16-mei-2017 om 17:00 heeft CIS-PIDD <cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>> het volgende geschreven:
Dear all,

I am planning to treat an ADA2 deficient patient with Infliximab and would like to know the dosage and the dosing intervall already used sucessfully.
Is it 5mg/kg at week 0, 2, 6 and thereafter every 8 weeks?

Thank you and best regards,

Fabian

Fabian Hauck, MD, PhD

Head Immunodeficiency Unit and Immunological Diagnostics Laboratoy
Pediatrics / Pediatric Hematology and Oncology / Immunology (DGfI)

Dr. von Hauner Children’s Hospital
Klinikum der Universität München
Lindwurmstr. 4, 80337 München
Germany

Tel.: +49 89 4400-53931
Fax: +49 89 4400-53964
E-Mail: fabian.hauck at med.uni-muenchen.de<mailto:fabian.hauck at med.uni-muenchen.de>

www.klinikum.uni-muenchen.de<http://www.klinikum.uni-muenchen.de/>

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Das Klinikum der Universität München ist eine Anstalt des öffentlichen Rechts (AöR)
The Klinikum der Universität München is an Institution under Public Law

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