[CIS PIDD] [cis-pidd] Dupilumab in DOCK8

[CIS-PIDD]

Hi Brian,

That's a very interesting idea.  I have not heard of dupilimab used in DOCK8, but given the mechanism, the only thing that would give me pause would be if your patient had cryptosporidium.

Best,
Mike



Michael D. Keller, MD

Assistant Professor, Division of Allergy / Immunology

Center for Cancer and Immunology Research

Jeffrey Modell Diagnostic and Research Center for

Primary Immunodeficiency Disorders

Children's National Health System

111 Michigan Ave NW, M7745A

Washington, DC 20010

Clinic: 202.476.2140

Office: 202.476.5843

Fax: 202.476.2280

www.ChildrensNational.org


________________________________
From: cis-pidd at lyris.dundee.net [cis-pidd at lyris.dundee.net] on behalf of CIS-PIDD [cis-pidd at lists.clinimmsoc.org]
Sent: Thursday, June 15, 2017 2:12 PM
To: CIS-PIDD
Subject: [cis-pidd] Dupilumab in DOCK8


O great and wise listserv:


Does anyone have any experience yet using dupilumab in DOCK8 deficient patients? I suspect it would help the atopic dermatitis (and perhaps other manifestations of allergic inflammation) that are quite clinically problematic in my patient; but am mainly wondering about any actual or theoretical off-target effects that should be considered in this population.


Many thanks

BPV


Brian P. Vickery, MD
Clinical Assistant Professor of Pediatrics
UNC-Chapel Hill
Campus Box #7231 | Chapel Hill, NC 27599
919.962.5136 (ph) | 919.962.4421 (f)
uncfoodallergy.org

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