[CIS PIDD] [cis-pidd] Varicella non-responders

[CIS-PIDD]

I wanted to know if anyone has experience with patients who do not respond to varicella vaccine. I had a 16 year old patient with mildly low IgM and IgA who received varicella
vaccine when he was 1 and 8 years old, history of chicken pox a few years after the first vaccine. Her varicella antibody titer was not protective.

Her immune work-up is below:
IgG 964, IgM 43, IgA 54
Lymphocyte subsets: CD3: 2415, CD4: 1331, CD8: 1053, CD16: 186, CD56: 155, CD19: 433
T-cell proliferation to PHA: 92% of control
Ab titers: Diphtheria and Tetanus protective, S. pneumoniae: 16/23 serotypes protective



Thank you for the input.
- Jay

Jay Patel, MD
Fellow, Allergy and Immunology
University of Washington




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