[CIS PIDD] [cis-pidd] Live Vaccines for AT babies diagnosed by SCID screen?

[CIS-PIDD]

Hello all,
Now that we are all diagnosing AT babies very early, is there a consensus on live vaccines?
Are people just doing it case by case based on CD4 and CD8 counts as well as proliferation?
Would people be willing to share what they do at their institution?

We just diagnosed a baby with AT who was picked up on NBS.  He is due for his 2 month vaccines.
CD4 count around 800, CD8 count count only 250, B cells very low around 80 cells/ul, normal NK cells,
Very decent proliferation with PHA and Pokeweed.
I want to say ok, but now with this concern about rubella positive granulomas in patients with AT linked with MMR, I am wondering if I should be more cautious.

Thank you for your thoughts,

Hey

Hey Jin Chong MD PhD
Division Director of Pediatric Allergy & Immunology
Assistant Professor of Pediatrics
Children's Hospital of Pittsburgh of UPMC
One Children's Hospital Drive
4401 Penn Avenue
Pittsburgh, PA 15224
tel 412-692-7885
fax 412-692-8499





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